Respiratory alkalosis and reduced plasmatic concentration of ionized calcium in rats treated with 1,25 dihydroxycholecalciferol
| Autor: | D. A. Caferra, María del Carmen Fernández, M. C. Gimenez, Rodolfo C. Puche, M. E. Locatto, M. C. Vidal |
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| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment chemistry.chemical_element Parathyroid hormone Calcium Kidney Parathyroid Glands Endocrinology Polyuria Calcitriol Internal medicine medicine Cyclic AMP Animals Orthopedics and Sports Medicine Calcium metabolism Dose-Response Relationship Drug Chemistry Biological activity Rats Inbred Strains medicine.disease Rats Steroid hormone Respiratory alkalosis Thyroidectomy Parathyroid hormone secretion medicine.symptom Alkalosis Respiratory |
| Zdroj: | Calcified tissue international. 36(5) |
| ISSN: | 0171-967X |
| Popis: | The daily administration of supraphysiological doses of 1,25 dihydroxycholecalciferol (0.1-2.5 micrograms/d/100 g body weight) to rats, produced respiratory alkalosis. With the doses of 0.1-0.2 micrograms/d/100 g and feeding a diet with 0.7% of calcium, calcemias did not exceed 2.75 mM, and significantly reduced plasma ionized calcium levels were measured. The latter phenomenon was found associated with increased urinary excretion of cAMP, soft tissue calcium content, and polyuria with hypostenuria, all known effects of parathyroid hormone. These effects were absent in thyroparathyroidectomized rats treated in the same fashion. Present results suggest that the stimulus of low levels of plasma ionized calcium overcomes the probably inhibitory effect of the steroid on parathyroid hormone secretion. |
| Databáze: | OpenAIRE |
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