Regional haemodynamic effects of mu-, delta-, and kappa-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats

Autor: Maryse Pitre, Hélène Bachelard
Jazyk: angličtina
Rok vydání: 1995
Předmět:
Male
medicine.medical_specialty
Pyrrolidines
Enkephalin
Microinjections
Receptors
Opioid
mu
Vasodilation
Blood Pressure
Rats
Inbred WKY
chemistry.chemical_compound
Renal Artery
Heart Rate
Internal medicine
Receptors
Opioid
delta
Tachycardia
medicine
Laser-Doppler Flowmetry
Animals
Opioid peptide
Mesenteric arteries
Antihypertensive Agents
Pharmacology
Analgesics
Receptors
Opioid
kappa
digestive
oral
and skin physiology
3
4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
(trans)-Isomer
Hemodynamics
Enkephalins
Enkephalin
Ala(2)-MePhe(4)-Gly(5)
Hindlimb
Mesenteric Arteries
Rats
DAMGO
medicine.anatomical_structure
Endocrinology
chemistry
Opioid
nervous system
Hypothalamus
Vasoconstriction
medicine.symptom
Enkephalin
D-Penicillamine (2
5)
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Research Article
Paraventricular Hypothalamic Nucleus
Popis: 1. The cardiovascular effects of bilateral injection into the hypothalamic paraventricular nuclei of selective mu-, delta-, and kappa-opioid receptor agonists were investigated in conscious, unrestrained Wistar Kyoto rats, chronically instrumented with pulsed Doppler flow probes for measurement of regional haemodynamics. 2. The selective mu-agonist [D-Ala2,MePhe4,Gly5ol]enkephalin (DAMGO), injected bilaterally into the hypothalamic paraventricular nuclei (0.01-1.0 nmol), caused increases in blood pressure, tachycardias, vasoconstriction in renal and superior mesenteric vascular beds and substantial vasodilatation in the hindquarter vascular bed. 3. The administration of increasing doses (0.01-5.0 nmol) of the selective delta-agonist [D-Phe2,5]enkephalin (DPDPE) or the selective kappa-agonist, U50488H into the paraventricular nuclei (PVN) had no significant effect on blood pressure, heart rate, or regional haemodynamics. 4. Together, the present results are further evidence of a role for opioid peptides, especially acting at mu-receptors in the PVN, in the central regulation of the cardiovascular system, whereas a role for opioid peptides, acting at delta- and kappa-receptors in the PVN, seems less obvious from the present results.
Databáze: OpenAIRE
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