Two Novel Nanoscale Preparations of Micelle and Thermosensitive Hydrogel for Docetaxel to Treat Malignant Tumor
| Autor: | Cheng Wang, Chaofeng Long, Bingyang Chu, Lan Zhang, Feng Luo, YuJun Wang, Xiaoxin Chen, Zhiyong Qian, Chengshi Xie |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Cell Survival Stereochemistry Polyesters Dispersity Biomedical Engineering H&E stain Pharmaceutical Science Medicine (miscellaneous) Antineoplastic Agents Bioengineering Docetaxel Hemolysis Micelle Hydrogel Polyethylene Glycol Dimethacrylate Polyethylene Glycols Mice chemistry.chemical_compound Neoplasms medicine Copolymer Animals Nanotechnology General Materials Science Cytotoxicity Micelles Mice Inbred BALB C Cell Death Body Weight Temperature Survival Analysis chemistry Female Taxoids Rabbits Particle size Ethylene glycol medicine.drug Nuclear chemistry |
| Zdroj: | Journal of Biomedical Nanotechnology. 9:357-366 |
| ISSN: | 1550-7033 |
| DOI: | 10.1166/jbn.2013.1440 |
| Popis: | In this paper, two nanoscale preparations were described for docetaxel encapsulation using poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) copolymer as carrier for treating malignant tumor. The first formulation was docetaxel-loaded PCEC micelle (D-M), which was characterized by XRD, TEM and Malvern laser particle size and drug release studies. The highest drug-loading of docetaxel in micelle was about 22.1 +/- 1.9%, optimized average diameter and polydispersity index was 25.2 +/- 1.1 nm, 0.13 +/- 0.12, respectively. Another formulation was docetaxel-loaded PCEC thermosensitive hydrogel (D-H), which displayed special gel-sol transition behavior with body temperature. We studied the cytotoxicity and in vitro hemolytic test of blank PCEC copolymer, the result was superiority. The data of relative body weight (RW), relative tumor volume (RV) and micrographs of hematoxylin and eosin (H&E)-stained histological sections showed D-M and D-H had significant antitumor effect and exhibited different characteristics of antitumor activity. Thus, the experiments signified that the combination therapy of intravenous (i.v.) and intratumoral administration using the two formulations maybe an effective way to treat malignant tumor. |
| Databáze: | OpenAIRE |
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