Influence of aging on oral-pharyngeal bolus transit and clearance during swallowing: scintigraphic study
| Autor: | Ian J. Cook, Martin Weltman, Karen L. Wallace, Richard C. Smart, S. P. Butler, Erin McKay, D. W. Shaw |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Aging Time Factors Glottis Physiology Oropharynx Transit time Normal aging Bolus (medicine) Swallowing Physiology (medical) medicine Humans Radionuclide Imaging Aged Aged 80 and over Hepatology business.industry digestive oral and skin physiology Gastroenterology Tin Compounds Mean age Middle Aged Deglutition Clearance time Technetium Compounds medicine.anatomical_structure Anesthesia Female Oral pharyngeal business |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 266:G972-G977 |
| ISSN: | 1522-1547 0193-1857 |
| Popis: | The aim of the study was to determine the influence of normal aging on regional transit and the efficiency of bolus clearance during the oral and pharyngeal phases of swallowing. We compared scintigraphically derived oral-pharyngeal transit times and isotope clearance during swallowing in 21 healthy aged volunteers (mean age 68 +/- 8 yr) and 9 young controls (mean age 28 +/- 7.5 yr). Subjects swallowed 5- and 10-ml water boluses mixed with 30 MBq 99mtechnetium tin colloid. Oral and pharyngeal transit times, pharyngeal clearance time, and postswallow residual counts in each region were derived from time-activity curves. Pharyngeal residual counts were significantly greater in the aged than in controls (P = 0.0008), but age did not influence oral residual. Aging significantly prolonged oral transit time (P = 0.02), pharyngeal transit time (P = 0.0004), and pharyngeal clearance time (P = 0.0001). We conclude that normal impairs the efficiency of pharyngeal clearance during swallowing, prolongs scintigraphic measures of oral-pharyngeal transit, and increases the exposure time of the glottis to the swallowed bolus. |
| Databáze: | OpenAIRE |
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