Adenosine plasma level correlates with homocysteine and uric acid concentrations in patients with coronary artery disease

Autor: Jean Ruf, Thomas Cuisset, Julien Fromonot, Jacques Quilici, Emmanuel Fenouillet, Laurie Bruzzese, Stefano Bonatti, Giovanna Mottola, Régis Guieu, Pierre Deharo
Přispěvatelé: Dysoxie, suractivité : aspects cellulaires et intégratifs thérapeutiques (DS-ACI / UMR MD2), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fromonot, J., Deharo, P., Bruzzese, L., Cuisset, T., Quilici, J., Bonatti, Stefano, Fenouillet, E., Mottola, Giovanna, Ruf, J., Guieu, Régis, CUISSET, Thomas
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Adenosine
Homocysteine
Physiology
030204 cardiovascular system & hematology
MESH: Uric Acid
Coronary artery disease
chemistry.chemical_compound
0302 clinical medicine
Tumor Cells
Cultured
MESH: Coronary Artery Disease
MESH: Aged
MESH: Middle Aged
Medicine (all)
General Medicine
homocystéine
Middle Aged
MESH: Case-Control Studies
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
MESH: Hyperhomocysteinemia
Female
coronary artery disease
medicine.drug
Hyperhomocysteinemia
medicine.medical_specialty
coronaropathie
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
Physiology (medical)
medicine
Humans
In patient
MESH: Tumor Cells
Cultured
MESH: Homocysteine
Aged
Pharmacology
adénosine
MESH: Humans
business.industry
Case-control study
Plasma levels
medicine.disease
MESH: Adenosine
MESH: Male
Uric Acid
030104 developmental biology
Endocrinology
chemistry
Case-Control Studies
Uric acid
business
MESH: Female
Zdroj: Canadian Journal of Physiology and Pharmacology
Canadian Journal of Physiology and Pharmacology, NRC Research Press, 2017, pp.272-7
Canadian Journal of Physiology and Pharmacology, 2017, pp.272-7
ISSN: 0008-4212
1205-7541
Popis: The role of hyperhomocysteinemia in coronary artery disease (CAD) patients remains unclear. The present study evaluated the relationship between homocysteine (HCys), adenosine plasma concentration (APC), plasma uric acid, and CAD severity evaluated using the SYNTAX score. We also evaluated in vitro the influence of adenosine on HCys production by hepatoma cultured cells (HuH7). Seventy-eight patients (mean age ± SD: 66.3 ± 11.3; mean SYNTAX score: 19.9 ± 12.3) and 30 healthy subjects (mean age: 61 ± 13) were included. We incubated HuH7 cells with increasing concentrations of adenosine and addressed the effect on HCys level in cell culture supernatant. Patients vs. controls had higher APC (0.82 ± 0.5 μmol/L vs 0.53 ± 0.14 μmol/L; p < 0.01), HCys (15 ± 7.6 μmol/L vs 6.8 ± 3 μmol/L, p < 0.0001), and uric acid (242.6 ± 97 vs 202 ± 59, p < 0.05) levels. APC was correlated with HCys and uric acid concentrations in patients (Pearson‘s R = 0.65 and 0.52; p < 0.0001, respectively). The SYNTAX score was correlated with HCys concentration. Adenosine induced a time- and dose-dependent increase in HCys in cell culture. Our data suggest that high APC is associated with HCys and uric acid concentrations in CAD patients. Whether the increased APC participates in atherosclerosis or, conversely, is part of a protective regulation process needs further investigations.
Databáze: OpenAIRE
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