Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles
| Autor: | Paula P Navarro, Alexandra Graff-Meyer, Jürgen Hench, Matthias E. Lauer, Bernd Bohrmann, Yvonne de Gier, Gabriel Schweighauser, Annemieke J.M. Rozemuller, Henning Stahlberg, Stephan Frank, Christel Genoud, Daniel Castaño-Díez, Sarah H Shahmoradian, Markus Britschgi, Amanda J Lewis, Wilma D.J. van de Berg |
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| Přispěvatelé: | Pathology, Amsterdam Neuroscience - Neurodegeneration, Anatomy and neurosciences |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CA2 Region Hippocampal lcsh:Medicine Article 03 medical and health sciences Imaging Three-Dimensional Organelle medicine Humans Aging brain lcsh:Science Pars Compacta Aged Aged 80 and over Inclusion Bodies Organelles Multidisciplinary Chemistry lcsh:R Brain Parkinson Disease Human brain Cell biology Microscopy Electron 030104 developmental biology medicine.anatomical_structure Cytoplasm Ultrastructure lcsh:Q Glymphatic system Autopsy Brainstem Corpora amylacea Brain Stem |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) Scientific Reports, 8(1):18046. Nature Publishing Group Navarro, P P, Genoud, C, Castaño-Díez, D, Graff-Meyer, A, Lewis, A J, de Gier, Y, Lauer, M E, Britschgi, M, Bohrmann, B, Frank, S, Hench, J, Schweighauser, G, Rozemuller, A J M, van de Berg, W D J, Stahlberg, H & Shahmoradian, S H 2018, ' Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles ', Scientific Reports, vol. 8, no. 1, 18046 . https://doi.org/10.1038/s41598-018-36223-4 Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclear so far, as has their relevance to aging and certain disease states that involve the sequestration of toxic cellular metabolites. Here, we apply correlative serial block-face scanning electron microscopy and transmission electron tomography to gain three-dimensional insight into the ultrastructure and surrounding microenvironment of cerebral Corpora amylacea in the human brainstem and hippocampal region. We find that cerebral Corpora amylacea are composed of dense labyrinth-like sheets of lipid membranes, contain vesicles as well as morphologically preserved mitochondria, and are in close proximity to blood vessels and the glymphatic system, primarily within the cytoplasm of perivascular glial cells. Our results clarify the nature of cerebral Corpora amylacea and provide first hints on how they may arise and develop in the aging brain. |
| Databáze: | OpenAIRE |
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