Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic, immunohistochemical, and p53 gene alteration analysis
| Autor: | Toshitaka Nagao, Yoshiro Ebihara, Akira Asoh, Tohru Shimizu, Keiichi Iwaya, Hiromi Serizawa, Isamu Sugano, Shigeru Munakata, Yasuo Ishida, Kazuto Yamazaki, Akiyoshi Konno |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adenoid cystic carcinoma Loss of Heterozygosity Biology Polymerase Chain Reaction Pathology and Forensic Medicine Acinic cell carcinoma Salivary duct carcinoma Loss of heterozygosity Neoplasms Multiple Primary medicine Carcinoma Biomarkers Tumor Humans Aged Aged 80 and over Salivary gland Middle Aged medicine.disease Genes p53 Salivary Gland Neoplasms Immunohistochemistry Parotid gland medicine.anatomical_structure Female |
| Zdroj: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 15(7) |
| ISSN: | 0893-3952 |
| Popis: | Hybrid carcinomas of the salivary gland are a recently defined and rare tumor entity, consisting of two histologically distinct types of carcinoma within the same topographic area. In this study, we examined nine such cases, which mainly arose in the parotid gland (seven cases), with an additional one each from submandibular and lacrimal glands, and analyzed their clinicopathologic profiles, including immunohistochemical features and p53 gene alterations. The prevalence of hybrid carcinomas was 0.4% among the 1863 cases of parotid gland tumors in our series. The nine patients comprised five men and four women, ranging in age from 40 to 81 years (mean, 62 y). Tumor size ranged from 2 to 10 cm (mean, 4.2 cm). Of the seven patients who were followed up, two were alive with disease and five were alive with no evidence of disease, although the follow-up period was short. Three cases had cervical lymph nodal metastases. The combinations of carcinoma components in our hybrid carcinomas were as follows: epithelial-myoepithelial carcinoma and basal cell adenocarcinoma in two cases, epithelial-myoepithelial carcinoma and squamous cell carcinoma in one case, salivary duct carcinoma and adenoid cystic carcinoma in two cases, myoepithelial carcinoma and salivary duct carcinoma in one, acinic cell carcinoma and salivary duct carcinoma in one, and squamous cell carcinoma and salivary duct carcinoma in two. Although the proportion of each carcinoma component in a tumor mass varied from case to case, the minor component always represented >or= 10% of the area. Differences in cellular composition were studied by immunohistochemistry and electron microscopy. The Ki-67-labeling index apparently differed between the two carcinoma elements in five cases. Diffusely positive p53 immunoreactivity was observed in four cases, restricted to the more aggressive component in each pair. Furthermore, p53 gene alteration analysis of these p53-positive cases revealed that all and three cases demonstrated loss of heterozygosity at p53 microsatellite loci and p53 gene point mutations, respectively, which were detected only in the p53-immunoreactive carcinoma component. Therefore, there is the possibility that such molecular-genetic events take an integral part for inducing the transformation from histologically lower to higher grade tumor during the hybrid carcinoma genesis of the salivary glands. |
| Databáze: | OpenAIRE |
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