A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene
| Autor: | Nadia Giarratana, Balan Rajan, Kannan Kamala, Michelle Mendenhall, Giorgio Reiner |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hypochlorous acid Population Nose medicine.disease_cause Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Viral load 030212 general & internal medicine Oral mucosa education Pandemics education.field_of_study business.industry SARS-CoV-2 COVID-19 Hygiene General Medicine Hypochlorous Acid Miscellaneous 030104 developmental biology medicine.anatomical_structure chemistry Otorhinolaryngology Hypochlorous acid (HClO) Acid-Oxidizing solution (AOS2020) Nasal administration Irritation business Oxidation-Reduction Upper respiratory tract Respiratory tract |
| Zdroj: | European Archives of Oto-Rhino-Laryngology |
| ISSN: | 1434-4726 |
| Popis: | Introduction To eliminate the COVID-19 pandemic, the transmission of the virus SARS-CoV-2 among the population needs to be blocked and/or at least reduced. Upper respiratory tract viral loads are highest in the early stages of the disease, and high loads are associated with higher mortality rates. This study aims to evaluate the virucidal efficacy of AOS2020, a novel sprayable Acid-Oxidizing solution containing pure and stable hypochlorous acid (HClO), on human coronavirus SARS-Cov-2 in vitro, and the tolerability profile on nasal and oral mucosa suggesting to be a potential solution for upper respiratory hygiene. Method Virucidal assays and intranasal and oral irritation tests were undertaken in accordance with relevant national and international guidance and methods. Results In pre-clinical tests, the AOS2020, showed > 99.8% virucidal efficacy in Conclusion These initial results indicate that this product has the potential treatment to reduce viral load in the upper respiratory tract. |
| Databáze: | OpenAIRE |
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