Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease
| Autor: | Maximiliano López Silva, Halina Grosman, Gabriela Berg, Viviana Mesch, Osvaldo Mazza, Bibiana Fabre, Carlos H. Scorticati, Miguel A. López |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Leptin Prostatic Diseases medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD medicine.medical_treatment Prostatic Hyperplasia 030232 urology & nephrology Ciencias de la Salud urologic and male genital diseases purl.org/becyt/ford/3.3 [https] 03 medical and health sciences Prostate cancer 0302 clinical medicine Insulin resistance Prostate Internal medicine Sex Hormones medicine Humans Insulin Testosterone Insulin-Like Growth Factor I Aged Metabolic Syndrome Estradiol business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Otras Ciencias de la Salud Prostate-specific antigen medicine.anatomical_structure Endocrinology Case-Control Studies 030220 oncology & carcinogenesis purl.org/becyt/ford/3 [https] Insulin Resistance Geriatrics and Gerontology Metabolic syndrome business |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1473-0790 1368-5538 |
| DOI: | 10.3109/13685538.2015.1100600 |
| Popis: | Objectives: To assess sex hormones, leptin and insulin-resistance in men with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and to study associations between androgens and histologic score of prostate tissue in PCa.Subjects and methods: Two hundred ten men older than 45 years selected from 2906 participants of a population screening for PCa were studied: 70 with PCa, 70 with BPH and 70 controls (CG), matched by body mass index and age. Insulin, IGF-1, PSA, leptin, total, free (fT) and bioavailable testosterone (bT) and estradiol were measured. Each group was subdivided into two subgroups considering the presence of metabolic syndrome (MS); androgens and leptin levels were analyzed in the subgroups.Results: Prostate cancer and BPH patients presented higher total, fT and bT levels than CG. IGF-1, insulin and HOMA index were higher in BPH than in the other two groups. PCa presented higher leptin [median (range) 6.5 (1.3-28.0) versus 4.8 (1.1-12.3) ng/ml; p < 0.01] and estradiol [median (range) 37.0 (20-90) versus 29.0 (20-118) pg/ml; p = 0.025] levels than CG. After dividing men considering the presence of MS, leptin was higher and total testosterone was lower in MS patients in all the groups.Conclusions: It was observed a coexistence of an altered hormone profile with increased sex hormones and leptin in PCa patients, in accordance with the new perspective of PCa pathogenesis. Fil: Grosman, Halina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Lopez, Miguel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Lopez Silva, Maximiliano. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Mesch, Viviana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Mazza, Osvaldo Néstor. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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