Effects of the valsartan/amlodipine combination and nifedipine gastrointestinal therapeutic system monotherapy on brachial pulse pressure and radial augmentation index in hypertensive patients
| Autor: | Shao-Kun Xu, Wei-Fang Zeng, Yan Li, Jian-Hong Xie, Liang-Long Chen, Ji-Guang Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Nifedipine Tetrazoles Blood Pressure 030204 cardiovascular system & hematology Assessment and Diagnosis 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Amlodipine Antihypertensive Agents Advanced and Specialized Nursing business.industry General Medicine Confidence interval Pulse pressure Treatment Outcome Blood pressure Valsartan Hypertension Ambulatory Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Blood Pressure Monitoring. 26:251-256 |
| ISSN: | 1359-5237 |
| DOI: | 10.1097/mbp.0000000000000527 |
| Popis: | Objective In a substudy of a randomized controlled trial, we investigated the effects of the valsartan/amlodipine single-pill combination and nifedipine gastrointestinal therapeutic system (GITS) monotherapy on brachial pulse pressure (bPP) and radial augmentation index (rAI) in patients with previously uncontrolled hypertension. Methods We performed measurements of clinic blood pressure (BP) and pulse rate and rAI (n = 63) and ambulatory BP monitoring (n = 42) at baseline and 12-week of follow-up. Analysis of covariance was performed to calculate the least square mean change from baseline and between-group differences [95% confidence interval (CI)]. Correlation analysis was performed to study the interrelationship between the changes in bPP and rAI and in pulse rate. Results After 12-week treatment, clinic and ambulatory SBP/DBP and pulse rate were not differently changed between the valsartan/amlodipine (n = 29) and nifedipine GITS groups (n = 34, P ≥ 0.06) except daytime SBP (P = 0.01). The reductions in 24-h and daytime ambulatory bPP were significantly greater in the former than the latter group (P ≤ 0.04). rAI increased slightly by 3.5% (P = 0.20) and 5.2% (P = 0.06) in the valsartan/amlodipine and nifedipine groups, respectively, with a between-group difference of -1.7% (95% CI -9.6 to 6.1%, P = 0.66). In the two groups combined, the changes in clinic and ambulatory bPP were not or weakly associated with that in clinic or ambulatory pulse rate (r = -0.14 to 0.36, P = 0.02-0.95), while the changes in rAI were more strongly or significantly associated with that in clinic or ambulatory pulse rate (r = -0.39 to -0.23, P = 0.02-0.16). Conclusions Antihypertensive drug-induced changes in rAI but not bPP were dependent on pulse rate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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