Characterization of shape memory polymer foam hemostats in in vitro hemorrhagic wound models
| Autor: | Anand Utpal Vakil, Nakira Christmas, Shi Dong, Christopher J Hatch, Henry T. Beaman, David Fikhman, Mary Beth B. Monroe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Polymers Swine Biomedical Engineering Hemorrhage 02 engineering and technology Specific adsorption In Vitro Techniques Hemostatics Biomaterials 03 medical and health sciences 0302 clinical medicine Battlefield In vivo Materials Testing Pressure Animals Humans Hemostat Hemostasis Wound Healing Temperature 030208 emergency & critical care medicine Equipment Design 021001 nanoscience & nanotechnology Bandages Elasticity Hemostasis Surgical Shape-memory polymer Disease Models Animal Smart Materials Liver Hemorrhage control Wounds Gunshot Glass 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of biomedical materials research. Part B, Applied biomaterialsREFERENCES. 109(5) |
| ISSN: | 1552-4981 |
| Popis: | Shape memory polymer foam hemostats are a promising option for future hemorrhage control in battlefield wounds. To enable their use as hemostatic devices, they must be optimized in terms of formulation and architecture, and their safety and efficacy must be characterized in animal models. Relevant in vitro models can be used for device optimization to help mitigate the excess use of animals and reduce costs of clinical translation. In this work, a simplified gunshot wound model and a grade V liver injury model were constructed. The models were used to characterize the effects of shape memory polymer foam hemostat geometry on wall pressures, application/removal times, hemorrhage (fluid loss), and fluid absorption in comparison with clinical controls. It was found that there is no benefit in over-sizing the hemostatic device relative to wound volume and that geometry effects are dependent upon the wound type. These models provide a rapid means for elucidation of promising hemostat geometries and formulations for use in future in vivo testing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text