Acute and chronic regulation of aldosterone production
| Autor: | William E. Rainey, Wendy B. Bollag, Lawrence O. Olala, Namita G. Hattangady |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Aldosterone synthase
endocrine system medicine.medical_specialty Time Factors medicine.drug_class Adrenocorticotropic hormone Models Biological Biochemistry Article chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Internal medicine Hyperaldosteronism medicine Animals Humans Aldosterone Molecular Biology Angiotensin II receptor type 1 biology Angiotensin II medicine.disease medicine.anatomical_structure chemistry Zona glomerulosa Mineralocorticoid Potassium biology.protein Steroids Metabolic Networks and Pathways hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular and Cellular Endocrinology. 350:151-162 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2011.07.034 |
| Popis: | Aldosterone is the major mineralocorticoid synthesized by the adrenal. Secretion of aldosterone is regulated tightly by the adrenocortical glomerulosa cells due to the selective expression of CYP11B2 in the outermost zone, the zona glomerulosa. Aldosterone is largely responsible for regulation of systemic blood pressure through the absorption of electrolytes and water under the regulation of certain specific agonists. Angiotensin II (Ang II), potassium (K+) and adrenocorticotropin (ACTH) are the main physiological agonists which regulate aldosterone secretion. The mechanisms involved in this process may be regulated minutes after a stimulus (acutely) through increased expression and phosphorylation of the steroidogenic acute regulatory (StAR) protein, over hours to days (chronically) by increased expression of the enzymes involved in the synthesis of aldosterone, particularly aldosterone synthase (CYP11B2). Imbalance in any of these processes may lead to several aldosterone excess disorders. In this review we attempt to summarize the key molecular events involved in and specifically attributed to the acute and chronic phases of aldosterone secretion. |
| Databáze: | OpenAIRE |
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