Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production

Autor: Mohammad Salajegheh, Remedios Nazareno, Anne P. Liao, Chris Morehouse, Ronald G. Jubin, Yihong Yao, Steven A. Greenberg, Bahija Jallal
Rok vydání: 2010
Předmět:
Myxovirus Resistance Proteins
Oxidoreductases Acting on CH-CH Group Donors
Transcription
Genetic
medicine.medical_treatment
Immunology
Gene Expression
Alpha interferon
Cell Count
Receptor
Interferon alpha-beta
Plasmacytoid dendritic cell
Interferon alpha-2
Biology
Article
GTP-Binding Proteins
Interferon
Endopeptidases
medicine
Humans
Protein Isoforms
Immunology and Allergy
Antigen-presenting cell
Receptor
Ubiquitins
Adaptor Proteins
Signal Transducing
Intracellular Signaling Peptides and Proteins
Antibodies
Monoclonal
Interferon-alpha
Proteins
RNA-Binding Proteins
hemic and immune systems
Dendritic Cells
Interferon-beta
Dendritic cell
Recombinant Proteins
Cell biology
Autocrine Communication
Kinetics
Cytokine
Oligodeoxyribonucleotides
Toll-Like Receptor 9
Interferon Type I
Leukocytes
Mononuclear
Cytokines
Carrier Proteins
Ubiquitin Thiolesterase
Interferon type I
medicine.drug
Zdroj: Clinical Immunology. 136:130-138
ISSN: 1521-6616
Popis: To determine the potential consequences of plasmacytoid dendritic cell (pDC) accumulation in tissue sites observed in several autoimmune diseases, we measured type 1 interferon production from circulating human pDCs as a function of pDC concentration. The effects of interferon-alpha and blockade of the type 1 interferon receptor (IFNAR) on human pDC type 1 interferon and interferon-inducible transcription and protein production were measured. Human pDCs became far more efficient producers of interferon-alpha at concentrations beyond those normally present in blood, through an IFNAR-dependent mechanism. Extracellular interferon-alpha increased pDC production of type 1 interferons. The accumulation of pDCs in diseased tissue sites allows marked non-linear amplification of type 1 interferon production locally. The role of the IFNAR-dependent mechanism of interferon production by human pDCs is greater than previously suggested. IFNAR blockade has potential for diminishing type 1 interferon production by all human cells.
Databáze: OpenAIRE
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