Eurotransplant donor-risk-index and recipient factors: influence on long-term outcome after liver transplantation - A large single-center experience

Autor:	Andreas Pascher, Andreas Andreou, Johann Pratschke, Marcus Bahra, Daniel Seehofer, Wenzel Schoening, Volker Schmitz, Michael Helbig, Niklas Buescher, Gero Puhl
Rok vydání:	2016
Předmět:	Graft Rejection Male medicine.medical_specialty Multivariate analysis medicine.medical_treatment 030230 surgery Liver transplantation Single Center Risk Assessment Gastroenterology 03 medical and health sciences Postoperative Complications 0302 clinical medicine Cholestasis Risk Factors Internal medicine medicine Humans Retrospective Studies Transplantation business.industry Liver Diseases Graft Survival Retrospective cohort study Hepatitis C Middle Aged Prognosis medicine.disease Tissue Donors Liver Transplantation Europe Cohort Female 030211 gastroenterology & hepatology Viral hepatitis business Follow-Up Studies
Zdroj:	Clinical Transplantation. 30:508-517
ISSN:	0902-0063
Popis:	The organ shortage has led to increased use of marginal organs. The Eurotransplant Donor-Risk-Index (ET-DRI) was established to estimate outcome after Liver Transplantation (LT). Currently, data on impact of ET-DRI on long-term outcome for different indications and recipient conditions are missing. Retrospective, single-center analysis of long-term graft survival (GS) of 1767 adult primary LTs according to indication, labMELDcategory (1: ≤18; 2: >18-25; 3: >25-35; 4: >35), and ET-DRI. Mean ET-DRI in our cohort was 1.63 (±0.43). One-, 10, and 15-yr GS was 83.5%, 63.3%, and 54.8%. Long-term GS was significantly influenced by ET-DRI. Accordingly, four ET-DRI categories were defined and analyzed with respect to underlying disease. Significant impact of these categories was observed for: Alcohol, cholestatic/autoimmune diseases (CD/AIH), and HCV, but not for HCC, HBV, cryptogenic cirrhosis, and acute liver failure. labMELD categories showed no significant influence on graft, but on patient survival. Matching ET-DRI categories with labMELD revealed significant differences in long-term GS for labMELDcategories 1, 2, and 3, but not 4. In multivariate analysis, HCV combined with ET-DRI > 2 and labMELDcategory 3 combined with ET-DRI > 2 emerged as negative predictors. To achieve excellent long-term graft survival, higher risk organs (ET-DRI > 1.4) should be used restrictively for patients with CD/AIH or HCV. Organs with ET-DRI > 2 should be avoided in patients with a labMELD of >25-35.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08aedd7cb3acc28c9dc01aa194e3b931 https://doi.org/10.1111/ctr.12714 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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