A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress
| Autor: | Jay M. Weiss, Harlan P. Jones, Beau A. Aldridge, Katherine A. Boss-Williams |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Pathology medicine.medical_specialty Lung Neoplasms Time Factors medicine.medical_treatment Immunology Cell Adenocarcinoma CD8-Positive T-Lymphocytes Article Metastasis 03 medical and health sciences 0302 clinical medicine Immune system Immunity Cell Line Tumor medicine Immunology and Allergy Animals Lymphocytes RNA Messenger B cell B-Lymphocytes Electroshock business.industry Cancer Neoplasms Experimental medicine.disease Rats Inbred F344 Rats Gene Expression Regulation Neoplastic Killer Cells Natural 030104 developmental biology Cytokine medicine.anatomical_structure Neurology 030220 oncology & carcinogenesis Cancer research Cytokines Female Neurology (clinical) business CD80 Stress Psychological |
| Zdroj: | Journal of neuroimmunology. 313 |
| ISSN: | 1872-8421 |
| Popis: | Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function. |
| Databáze: | OpenAIRE |
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