Synthesis and Antifungal Activity of Diamidomethane Linked Oxazolyl/thiazolyl/imidazolyl Isoxazoles
| Autor: | S. Jyothi, M. Madhusekhar, G. Sravya, Grigory V. Zyryanov, A. Padmaja |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Zdroj: | AIP Conf. Proc. AIP Conference Proceedings |
| Popis: | Nitrogen containing heterocyclic compounds have great utility in synthetic, medicinal and material chemistry. Oxazole, isoxazole, thiazole, imidazole and their derivatives have gained prominence as they constitute the structural features of many bioactive compounds. In fact, amide functionality represents a privileged scaffold of biomolecules and many drugs. The combination of two or more heterocycles linked by amide functionality into one molecular framework would yield new chemical entities with enhanced pharmacological activities. Besides, development of environmentally benign methods with improved yields is highly desirable. In our continued interest to synthesize a variety of bioactive heterocycles, we planned to develop some new isoxazoles in combination with oxazoles / thiazoles / imidazoles adopting green methodologies and to study their antifungal activity. The results related to these aspects will be presented. © 2022 Author(s). |
| Databáze: | OpenAIRE |
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