Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications
| Autor: | Alessandro Barge, Peter Bielecki, Agata A. Exner, Federica Bosca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Porphyrins
Cell Survival Sonication Biomedical Engineering Cancer therapy Contrast Media Pharmaceutical Science Bioengineering Poloxamer 02 engineering and technology 010402 general chemistry 01 natural sciences Theranostic Nanomedicine chemistry.chemical_compound Cell Line Tumor Humans Ultrasonography Pharmacology chemistry.chemical_classification Reactive oxygen species Microbubbles Organic Chemistry Sonodynamic therapy 021001 nanoscience & nanotechnology Porphyrin In vitro 0104 chemical sciences chemistry Biophysics Colorectal Neoplasms Reactive Oxygen Species 0210 nano-technology Biotechnology |
| Popis: | Sonodynamic therapy (SDT) has become a promising noninvasive approach for cancer therapy. The treatment exploits the ability of particular molecules (i.e., porphyrins) to be excited by ultrasound and produce reactive oxygen species (ROS) during their decay process. These reactive species, in turn, result in cell death. To capitalize on the real-time visualization and on-demand delivery of ultrasound contrast agents, this study aims to combine porphyrins with nanobubbles (NBs) to obtain an ultrasound-activated theranostic agent that exploits the SDT activity in vitro. Two porphyrin classes, exposing different hydrophobic side chains, were synthesized. NB size and encapsulation efficiency were markedly dependent on the porphyrin structure. The combination of these porphyrin and NBs resulted in a significant reduction in cell viability upon sonication in pilot studies performed on the LS 174T colorectal cancer cell line. |
| Databáze: | OpenAIRE |
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