In-Hospital Safety and Effectiveness of Bivalirudin in Percutaneous Peripheral Interventions: Data From a Real-World Registry
| Autor: | Andrew N. Shammas, Gail A. Shammas, Nicolas W. Shammas, Eric J. Dippel, Michael Jerin |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Hemorrhage Constriction Pathologic Risk Assessment Severity of Illness Index law.invention Randomized controlled trial Ischemia Risk Factors law Angioplasty medicine Humans Bivalirudin Radiology Nuclear Medicine and imaging Registries Aged Retrospective Studies Aged 80 and over Peripheral Vascular Diseases Inpatients Chi-Square Distribution Heparin business.industry Anticoagulant Anticoagulants Retrospective cohort study Critical limb ischemia Hirudins Middle Aged Iowa Peptide Fragments Recombinant Proteins Surgery Radiography Logistic Models Treatment Outcome Amputation Direct thrombin inhibitor Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Endovascular Therapy. 17:31-36 |
| ISSN: | 1545-1550 1526-6028 |
| DOI: | 10.1583/09-2810.1 |
| Popis: | PURPOSE To present real-world data to evaluate the safety and effectiveness of bivalirudin, a direct thrombin inhibitor, in an unselected group of patients undergoing percutaneous peripheral interventions (PPI). METHODS Data were extracted from a prospectively collected peripheral vascular registry developed for quality assurance measures at 2 centers. Of 398 consecutive patients (195 men; mean age 69.4+/-11.3 years) who underwent PPI in a 2-year period, 369 (92.7%) received bivalirudin (0.75 mg/kg bolus followed by a 1.75 mg/kg/h infusion) and 29 (7.3%) received unfractionated heparin (UFH). In the bivalirudin sample, critical limb ischemia was present in 28.0% of patients, TASC D lesion in 29.5%, and angiographic thrombus in 7.8% of vessels. Demographic, clinical, procedural, and angiographic variables and in-hospital complications were analyzed. All in-hospital adverse events were independently adjudicated. RESULTS Procedural success ( |
| Databáze: | OpenAIRE |
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