Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
| Autor: | Jane S. Martins, Asit B. Neogy, Otamires A. Silva, Sylvie Boisnic, Maria Edileuza Felinto de Brito, Ioannis Vouldoukis, Loic Monjour, Márcio Martins Lobo Jardim, Nicole Vignot, Annette Lesot |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Microbiology (medical) lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 T-Lymphocytes medicine.medical_treatment lcsh:QR1-502 Leishmaniasis Cutaneous Antigens Protozoan chemotherapy Leishmania braziliensis lcsh:Microbiology Immune system Cutaneous leishmaniasis Antigen medicine Animals Humans Parasite hosting Child Antigens Bacterial Chemotherapy business.industry Macrophages Immunotherapy Middle Aged medicine.disease human cutaneous leishmaniasis Child Preschool Immunology Immunohistochemistry Antimonial Female immunotherapy business Brazil |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 89, Iss 3, Pp 479-483 (1994) Memórias do Instituto Oswaldo Cruz, Volume: 89, Issue: 3, Pages: 479-483, Published: SEP 1994 |
| ISSN: | 0074-0276 |
| Popis: | In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process. |
| Databáze: | OpenAIRE |
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