Effects of dietary n-3 fatty acids on the composition of cholesteryl esters and triglycerides in plasma and liver perfusate of the rat
| Autor: | Petr Hrabák, Karel Hátle, Edita Šindelková, P. Mareš, Antonín Vrána, Aleš Ẑák, J. Skořepa, Miroslav Zeman |
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| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics biology Triglyceride Cholesterol Endocrinology Diabetes and Metabolism Clinical Biochemistry Fatty acid Fish oil Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Saturated fatty acid Cholesterylester transfer protein medicine biology.protein lipids (amino acids peptides and proteins) Molecular Biology Unsaturated fatty acid Polyunsaturated fatty acid |
| Zdroj: | The Journal of nutritional biochemistry. 1(9) |
| ISSN: | 0955-2863 |
| Popis: | The effects of polyunsaturated fatty acids of the omega-3 family (PUFA n -3), (addition of fish oil), on the molecular composition of cholesteryl esters and triglycerides in plasma and liver perfusate of rats were studied. Rats fed a diet rich in saturated fatty acids (addition of lard) served as controls. Supplemention with PUFA n -3 not only decreases the plasma concentrations of free cholesterol, cholesteryl esters, and triglycerides, it also significantly alters the plasma composition of cholesteryl esters and triglycerides. Analyses of liver perfusate indicate a decrease in triglycerides secretion by in vitro perfused liver and reciprocal changes in relative contents of cholesteryl esters fractions with C 16 and C 20 acyl chains. This finding may be a result of chain-shortening of long-chain fatty acids probably in peroxisomal beta-oxidative system. Alterations in plasma cholesteryl esters and triglycerides composition of the fish oil group could be affected further by additional factors such as increased plasma cholesterol esterification activity and presence of triglyceride species of intestinal origin. |
| Databáze: | OpenAIRE |
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