Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli

Autor: Antonello Novelli, Hongna Pan, Z. Guo, Ann M. Marini, M. P. Mattson, Xueying Jiang, Xuan Wu, Nicolas Blondeau, Robert H. Lipsky
Přispěvatelé: Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Department of Psychology, University of Oviedo, Department of Neurology and Neurosciences Program, University of Health Sciences, Laboratory of Neurosciences, National Institutes of Health, Laboratory of Neurogenetics
Jazyk: angličtina
Rok vydání: 2007
Předmět:
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Clinical Biochemistry
Excitotoxicity
MESH: Neurons
Hippocampus
MESH: NF-kappa B
medicine.disease_cause
MESH: Brain-Derived Neurotrophic Factor
Biochemistry
MESH: Ischemic Preconditioning
0302 clinical medicine
Neurotrophic factors
Ischemia
Receptors
MESH: Animals
MESH: Memory
Hypoxia
Ischemic Preconditioning
Neurons
0303 health sciences
Neurogenesis
Glutamate receptor
NF-kappa B
Brain
MESH: Glutamic Acid
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
MESH: Seizures
Adaptation
Physiological
MESH: N-Methylaspartate
Anesthesia
MESH: Calcium
Hypoxia-Ischemia
Brain
NMDA receptor
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurotrophin
N-Methylaspartate
Physiological
Glutamic Acid
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
MESH: Calcium Signaling
Neuroprotection
Receptors
N-Methyl-D-Aspartate
03 medical and health sciences
Memory
Seizures
medicine
Animals
Humans
Learning
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Calcium Signaling
Adaptation
030304 developmental biology
MESH: Receptors
N-Methyl-D-Aspartate
MESH: Humans
Brain-Derived Neurotrophic Factor
Organic Chemistry
MESH: Adaptation
Physiological
nervous system
biology.protein
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Calcium
MESH: Hypoxia-Ischemia
Brain
MESH: Learning
Neuroscience
metabolism
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Amino Acids
Amino Acids, Springer Verlag, 2007, 32 (3), pp.299-304. ⟨10.1007/s00726-006-0414-y⟩
ISSN: 0939-4451
1438-2199
DOI: 10.1007/s00726-006-0414-y⟩
Popis: International audience; The amino acid glutamate, the major excitatory neurotransmitter in the central nervous system, activates receptors coupled to calcium influx. Excessive activation of glutamate receptors in conditions such as severe epileptic seizures or stroke can kill neurons in a process called excitotoxicity. However, subtoxic levels of activation of the N-methyl-D-aspartate (NMDA) type of glutamate receptor elicit adaptive responses in neurons that enhance their ability to withstand more severe stress. A variety of stimuli induce adaptive responses to protect neurons. For example, sublethal ischemic episodes or a mild epileptic insult can protect neurons in a process referred to as tolerance. The molecular mechanisms that protect neurons by these different stressful stimuli are largely unknown but they share common features such as the transcription factor, nuclear factor kappa B (NF-kappaB), which is activated by ischemic and epileptic preconditioning as well as exposure to subtoxic NMDA concentrations. In this article, we describe stress-induced neuroprotective mechanisms highlighting the role of brain-derived neurotrophic factor (BDNF), a protein that plays a crucial role in neuronal survival and maintenance, neurogenesis and learning and memory.
Databáze: OpenAIRE
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