Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection
| Autor: | Ondřej Beran, Michal Holub, Alžběta Davidová, David A. Lawrence, Nancy Andersen, Pavel Chalupa, Vilma Marešová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Calcitonin Male Interleukin 2 Chemokine Adolescent Article Subject Calcitonin Gene-Related Peptide Immunology Biology Procalcitonin Proinflammatory cytokine Young Adult medicine lcsh:Pathology Humans Interleukin 8 Protein Precursors Aged Aged 80 and over Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-8 C-reactive protein Bacterial Infections Cell Biology Middle Aged Community-Acquired Infections Interleukin 1 Receptor Antagonist Protein C-Reactive Protein Clinical Study biology.protein Cytokines Interleukin-2 Biomarker (medicine) Female Tumor necrosis factor alpha Interleukin-4 Chemokines Biomarkers medicine.drug lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2013 (2013) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-α, INF-γ, MIP-1β, and MCP-1. Bacterial etiology of infection was associated with significantly (P<0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-αin comparison to levels observed in the sera of patients with viral infections. In the patients with bacterial infections, IL-1Ra and IL-8 demonstrated positive correlation with C-reactive protein, whereas, IL-1Ra, TNF-α, and MCP-1 correlated with procalcitonin. Furthermore, elevated levels of IL-1Ra, IL-6, and TNF-αdecreased within 3 days of antibiotic therapy to levels observed in control subjects. The results show IL-1Ra as a potential useful biomarker of community-acquired bacterial infection. |
| Databáze: | OpenAIRE |
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