Pituitary-ovarian response to the gonadotrophin-releasing hormone-agonist test in anovulatory patients with polycystic ovary syndrome: predictive role of ovarian stroma
| Autor: | Mario Ciampelli, A. Iuculano, Antonio Lanzone, A. M. Fulghesu, Stefano Angioni, C. Belosi, Rosanna Apa, Luigi Selvaggi, G. B. Melis |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Pituitary gland medicine.medical_specialty Endocrinology Diabetes and Metabolism Gonadotropin-releasing hormone Biology Anovulation Diagnosis Differential Gonadotropin-Releasing Hormone Endocrinology Stroma Ovarian Follicle Internal medicine medicine Humans Testosterone Androstenedione Prospective Studies Ultrasonography Estradiol 17-alpha-Hydroxyprogesterone Ovary Luteinizing Hormone medicine.disease Polycystic ovary Androgen secretion medicine.anatomical_structure Case-Control Studies Pituitary Gland Androgens Female Follicle Stimulating Hormone Endocrine gland Polycystic Ovary Syndrome |
| Zdroj: | Clinical endocrinology. 65(3) |
| ISSN: | 0300-0664 |
| Popis: | Summary Objective To evaluate the influence of ovarian stroma on basal and poststimulus androgen secretion in patients affected by secondary amenorrhoea and polycystic ovaries (PCO) at ultrasound (US). Design Prospective study. Patients Fifty-one patients with PCO selected from a group of 72 normal weight women aged 20–25 years affected by secondary amenorrhoea and 10 normal ovulatory controls. Methods All subjects underwent US to evaluate volume, area, stromal area and stromal/total area ratio of both ovaries. Plasma levels of gonadotrophins, oestradiol (E2) and androgens were measured before and 24 h after GnRH-a injection. 60 min after stimulus LH and FSH were also assayed. Results Thirty patients had increased ovarian stroma (IS) and 21 patients normal ovarian stroma (NS). Significantly higher LH levels characterized the IS group, both basally and after GnRH-a stimulation compared with NS and controls (P |
| Databáze: | OpenAIRE |
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