Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico
| Autor: | Michelle M. Martínez-Montemayor, Luis A. Cubano, Gerónimo Maldonado-Martínez, Jannette Gavillán-Suárez, Wanda M. Figueroa-Cuilan, Natalie Rivera-Ortiz, Lorelein Morales-Santiago, Alexandra Aguilar-Perez, Karla Rodríguez-Tirado |
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| Rok vydání: | 2015 |
| Předmět: |
Costus speciosus
Blood Glucose Male food.ingredient Syzygium jambos Syzygium Tapeinochilos ananassae ved/biology.organism_classification_rank.species Zingiberales Decoction Mice food Diabetes mellitus Diabetes adjuvants Animals Hypoglycemic Agents Medicine Chemical profile biology Traditional medicine Plant Extracts business.industry ved/biology Puerto Rico General Medicine C57BLKS/J db/db and C57BL/J ob/ob mice biology.organism_classification medicine.disease Thin-layer chromatography 3. Good health Mice Inbred C57BL Complementary and alternative medicine Phytochemical Tapeinochilus ananassae business Costus Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-015-0772-7 |
| Popis: | Background The increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Puerto Rico has the highest rate of Type 2 diabetes within all the states and territories of the United States, and Puerto Ricans commonly use plants as diabetes adjuvants, it is important to study the plants’ physiological effects, and identify their bioactive compounds to understand their role in modulation of blood glucose levels. We present the phytochemical profiles and hypoglycemic effects of Tapeinochilus ananassae, Costus speciosus and Syzygium jambos. Methods Phytochemicals in methanolic and aqueous extracts were analyzed by thin layer chromatography (TLC). Alkaloids (Bromocresol green, λ = 470 nm), flavonoids (AlCl3, λ = 415 nm), saponins (DNS, λ = 760 nm), tannins (FeCl3/K4Fe(CN)6, λ = 395 nm) and phenolics (Folin-Ciocalteau, λ = 765 nm) were quantified. Male C57BLKS/J (db/db) and C57BL/J (ob/ob) genetically obese mice were orally gavaged with aqueous extracts of lyophilized plant decoctions for 10wks. Results Our results show that T. ananassae had significantly greater amounts of flavonoids and tannins, while S. jambos showed the greatest concentration of phenolics and C. speciosus exhibited higher amounts of alkaloids. C57BLKS/J db/db treated with plant extracts show better glucose modulation when the extracts are administered in complement with an insulin injection. Finally, C57BL/J ob/ob mice on T. ananassae and S. jambos treatments show better blood glucose modulation over time. Conclusion These results document for the first time the chemical profile of T. ananassae and provide evidence for a potential anti-diabetic efficacy of T. ananassae and S. jambos. Electronic supplementary material The online version of this article (doi:10.1186/s12906-015-0772-7) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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