The prevalence of HR-HPV infection based on self-sampling among women in China exhibited some unique epidemiologic features
| Autor: | Jerome L. Belinson, Xinfeng Qu, Ruifang Wu, Hongxue Luo, Hui Du, Chun Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
China medicine.medical_specialty Genotype Epidemiology Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Sampling Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Prevalence Humans Medicine Pooled data 030212 general & internal medicine Human papillomavirus Papillomaviridae Hpv types business.industry Screening Trial Papillomavirus Infections Genetic Variation virus diseases Middle Aged medicine.disease female genital diseases and pregnancy complications Population Surveillance Female Self Report business 030217 neurology & neurosurgery Self sampling |
| Zdroj: | Journal of Clinical Epidemiology. 139:319-329 |
| ISSN: | 0895-4356 |
| DOI: | 10.1016/j.jclinepi.2021.06.009 |
| Popis: | Objective To investigate the epidemiological characteristics of high-risk human papillomavirus(HR-HPV) infection based on vaginal self-collected samples. Study Design and Setting The pooled data of 3045 self-collected samples used for the analysis derived from four previous studies on cervical cancer screening(The Chinese Multi-Center Screening Trial, CHIMUST; The Shenzhen Cervical Cancer Screening Trial-2, SHENCCAST-2; The Chinese Cervical Cancer Prevention Study, CHIPCAPS; Pingshan trial, PINGSHAN)conducted across China by our team since 2011. These cases were evaluated for HR-HPV type prevalence relative to lesion grade and age. The occurrence of cervical intraepithelial neoplasia(CIN) with specific HPV types and the influence of co-infection is explored. Results The top three most common genotypes among the HR-HPV positives were HPV-52(23.4%), HPV-16(18.0%), and HPV-58(15.50%). For women with CIN2+, the most frequent genotypes were HPV-16, 58, 52, and 18 in sequence. HPV-16 accounted for the majority of CIN2/CIN3/Ca with attribution rate of 23.86%, 44.78% and 50.00% respectively. HPV-58 accounted for 19.48%, 16.79% and 13.46% respectively. CIN2+ was found in the following types most frequently: HPV-16(31.23%), HPV-33(24.03%), HPV-58(18.41%), HPV-31(11.76%), HPV-18(7.75%), and HPV-52(7.30%). HPV-16 showed preference for co-infection with HPV-52 and HPV-58. Conclusion The prevalence of HR-HPV infection based on self-sampling among women in China exhibited some unique epidemiologic features. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect