Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31
| Autor: | Jin Tian Li, Pei Hong Wu, Shi Juan Mai, Qi Jing Wang, Shi Ping Chen, Qi Sheng Feng, Yi Xing Zeng, Li Xi Huang, You Qing Zhan, Qin Fan, Zhi Zhong Pan, De Sheng Weng, Hai De Qin, Xing Juan Yu, Bing Jian Feng, Jian Chuan Xia, Jia He, Wen lin Huang, Yong Qiang Li |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research Loss of Heterozygosity Locus (genetics) Biology medicine.disease_cause Loss of heterozygosity Stomach Neoplasms Genotype Genetics medicine Humans Genes Tumor Suppressor Allele Molecular Biology Genotyping Gene Aged Middle Aged Physical Chromosome Mapping Cancer research Microsatellite Female Chromosome Deletion Carcinogenesis Chromosomes Human Pair 7 Microsatellite Repeats |
| Zdroj: | Cancer Genetics and Cytogenetics. 166:166-172 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2005.11.005 |
| Popis: | Gastric carcinoma is one of the most common malignancies in Asia. Although the allelic deletion of 7q has been reportedly associated with primary gastric carcinoma tumorigenesis, no predisposing genes in this region have been identified so far. Here, we report the results of genotype and loss of heterozygosity (LOH) analysis on 7q in this tumor. A panel of nine microsatellite markers distributed over the whole chromosome 7q was used for genotyping primary gastric carcinomas. Of 72 primary tumors LOH of D7S486 occurred in 24.0% (12/50) of cases. Fine mapping with 12 additional markers flanking D7S486 resulted in LOH of 30.36% (17/56) and defined one minimal deleted region in primary gastric carcinomas, a 90-kilobase region bounded by D7S2543 and D7S486 at 7q31.2. The allelic deletion correlates statistically with clinicopathologic variables. Our data suggest a possible link between putative tumor suppressor genes and gastric carcinoma in the 7q31 region. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect