B-cell tolerance
| Autor: | Teresa Lambe, Anastasia Nijnik, Karlee Silver, Richard J. Cornall, Helen Ferry, Graham Lewis, Janson C. H. Leung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Clonal Anergy
B-Lymphocytes Transplantation Clonal anergy T cell Receptor editing Autoimmunity T-Lymphocytes Helper-Inducer Biology medicine.disease_cause Autoantigens Immune system medicine.anatomical_structure Transplantation Immunology Immunology medicine Humans Tissue specific Transplantation Tolerance Homeostasis B cell |
| Popis: | Autoreactive B cells are actively tolerized to more abundant self-antigens by a series of checkpoints involving receptor editing, deletion, anergy and competition for growth factors. In contrast, B cells reactive against rare, sequestered or tissue specific self-antigens remain functionally naïve. During an immune response, the autoimmune danger from these cells is countered by a variety of mechanisms comprising control of self-antigen presentation, limitation of immunogenic and tolerogenic costimuli including T cell help, homeostatic control of growth and strict regulation of germinal centre reactions. In this overview we consider how knowledge of these checkpoints may be used to gain a better understanding of transplant tolerance and the generation of alloantibodies. |
| Databáze: | OpenAIRE |
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