Peripheral muscle composition and health status in patients with COPD
| Autor: | Noelina Hernández, Elizabeth Gutiérrez Romero, Carlos Tálamo, Abdón Mata, Sonia H. Torres, Yudith Gonzalez, Maria Montes de Oca |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Spirometry Pulmonary and Respiratory Medicine medicine.medical_specialty Vital capacity Vastus lateralis muscle Health-related quality of life Vital Capacity Skeletal muscle Health status Body Mass Index Quadriceps Muscle Pulmonary Disease Chronic Obstructive FEV1/FVC ratio Forced Expiratory Volume Internal medicine medicine Humans Aged Aged 80 and over Emphysema COPD medicine.diagnostic_test business.industry Chronic obstructive pulmonary disease Biopsy Needle Respiratory disease Middle Aged Stepwise regression medicine.disease respiratory tract diseases Dyspnea Physical therapy Blood Gas Analysis business Body mass index |
| Zdroj: | Respiratory Medicine. 100(10):1800-1806 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2006.01.020 |
| Popis: | Summary Study objective The present study evaluated the relationship between health status (HS) and peripheral muscle histochemical characteristics in chronic obstructive pulmonary disease (COPD), and identified selected independent respiratory and extrapulmonary variables that predicted the HS of these patients. Design Cross-sectional study. Setting Outpatient respiratory clinic of a university hospital. Patients and methods We studied 29 patients (63±10 yrs) with a forced expiratory volume in 1 s (FEV1) of 39±12%. All patients underwent vastus lateralis muscle biopsies for histochemical analysis. They also had spirometry, arterial blood gas analysis, body mass index (BMI), dyspnea determined with the MMRC scale and responded to the St. George's Respiratory Questionnaire (SGRQ) for HS assessment. Results SGRQ total score correlated with fiber type distribution. A stepwise multiple regression identified three independent predictors of SGRQ total score: type I fiber proportion, BMI, and FEV1; r = 0.78 and r 2 = 0.61 . Conclusions These results indicate that impaired HS in COPD is related to the peripheral muscle changes characterized by less type I fibers proportion. The findings argue in favor of an important contribution of the systemic consequences on the HS in COPD independently from the airflow limitation severity, and help to explain the observation of the poor correlation between the degree of airflow limitation and SGRQ total score. |
| Databáze: | OpenAIRE |
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