Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats
Autor: | Seham S. Kassem, Madeha M. Abdelkader, Sahar B. Gomma, Hala M. Abdelkarem, Mervat A. El-Sherif |
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Rok vydání: | 2021 |
Předmět: |
Blood Glucose
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Adipokine Streptozocin Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Olive leaf Adipokines Olea Internal medicine Diabetes mellitus Animals Hypoglycemic Agents Insulin Medicine Pharmacology (medical) Rats Wistar Triglycerides 030109 nutrition & dietetics Nutrition and Dietetics Adiponectin medicine.diagnostic_test business.industry 030229 sport sciences Streptozotocin medicine.disease Rats Plant Leaves Endocrinology Powders business Lipid profile Food Science Lipoprotein medicine.drug |
Zdroj: | Journal of Dietary Supplements. 19:550-565 |
ISSN: | 1939-022X 1939-0211 |
Popis: | Olives (Olea europaea) have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200-225 g were divided into four groups (n = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2.0% OLP. The experiment was conducted for four weeks. Our results showed that the consumption of 2.0% OLP decreased serum glucose, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, whereas serum high density lipoprotein (HDL) level was increased. OLP supplementation also inhibited the atherogenic index [AI; log (TG/HDL-C) and atherogenic coefficient (AC)] levels relative to those of the untreated diabetic group. Moreover, OLP increased serum adiponectin concentration, and decreased serum leptin concentration. Liver and kidney functions were also attenuated by OLP. This finding also implies that OLP can play an important role in the treatment and delay of diabetic complications. |
Databáze: | OpenAIRE |
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