Lipoic acid based core cross-linked micelles for multivalent platforms: design, synthesis and application in bio-imaging and drug delivery
| Autor: | Jingsheng Huang, Shiyong Zhang, Haolong Huang, Fang Wu, Yunlong Yu, Jingsong You |
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| Rok vydání: | 2017 |
| Předmět: |
Biocompatibility
Biocompatible Materials Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Micelle chemistry.chemical_compound Bio imaging Drug Delivery Systems Cell Line Tumor Amphiphile Humans Physical and Theoretical Chemistry Micelles Thioctic Acid Chemistry Optical Imaging Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Lipoic acid Cross-Linking Reagents Design synthesis Drug delivery lipids (amino acids peptides and proteins) 0210 nano-technology HeLa Cells |
| Zdroj: | Organic & Biomolecular Chemistry. 15:4798-4802 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c7ob00927e |
| Popis: | Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. The presence of numerous disulfides accumulated in the core makes the micelles readily cross-linked to achieve the establishment of core cross-linked micelles (CCMs). Thanks to the inherent biocompatibility, the resulting lipoic acid based CCMs (LA-CCMs) are good multivalent platforms for biomedical applications. |
| Databáze: | OpenAIRE |
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