Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses
| Autor: | Masoom A. Haider, Sean R.H. Davidson, Mostafa M. Elhilali, Joanne Savard, Arjen Bogaards, John Trachtenberg, Brian C. Wilson, Andrew Evans, Mark R. Gertner, Robert A. Weersink, Joseph L. Chin, Avigdor Scherz |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Biopsy Urology medicine.medical_treatment Prostate cancer Prostate medicine Carcinoma Humans External beam radiotherapy Radiation treatment planning Bacteriochlorophylls Dose-Response Relationship Drug medicine.diagnostic_test business.industry Prostatic Neoplasms Cancer Prostate-Specific Antigen medicine.disease Magnetic Resonance Imaging Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Photochemotherapy Neoplasm Recurrence Local business |
| Zdroj: | BJU International. 102:556-562 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2008.07753.x |
| Popis: | OBJECTIVE To report on the efficacy of TOOKAD® (WST 09; NegmaLerads, Magny-Les-Hameaux, France) vascular-targeted photodynamic therapy (VTP) as a method of whole-prostate ablation in patients with recurrent localized prostate cancer after the failure of external beam radiotherapy (EBRT). PATIENTS AND METHODS Patients received a fixed photosensitizer dose of 2 mg/kg and patient-specific light doses as determined by computer-aided treatment planning. Up to six cylindrical light-diffusing delivery fibres were placed transperineally in the prostate under ultrasonographic guidance. The treatment response was assessed by measuring serum prostate-specific antigen (PSA) levels, lesion formation (avascular areas of tissue) measured on 7-day gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI) and a 6-month biopsy. RESULTS Treatment of the whole prostate was possible with minimal effects on surrounding organs. An increased light dose improved the tissue response, with MRI-detectable avascular lesions, encompassing up to 80% of the prostate in some patients. A complete response, as determined by the 6-month biopsy, required that patients received light doses of at least 23 J/cm2 in 90% of the prostate volume (D90 > 23 J/cm2). Of the 13 patients who received at least this light dose, eight were biopsy-negative at 6 months. In this group of eight patients, PSA levels decreased and did so to negligible levels for those patients with a baseline PSA level of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|