Evaluation of cytokines and sialic acids contents in horses naturally infected with Theileria equi
| Autor: | Bijan Esmaeilnejad, Seyyed Meysam Abtahi Foroushani, Elahe Mostafavi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
040301 veterinary sciences
medicine.medical_treatment 030231 tropical medicine Immunology Inflammation Parasitemia Biology Microbiology 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Interferon Theileria medicine Immunology and Allergy Animals Horses General Veterinary Horse 04 agricultural and veterinary sciences General Medicine DNA Protozoan medicine.disease Sialic acid Theileriasis Infectious Diseases Theileria equi Cytokine chemistry Sialic Acids Cytokines Tumor necrosis factor alpha Female Horse Diseases medicine.symptom medicine.drug |
| Zdroj: | Comparative immunology, microbiology and infectious diseases. 70 |
| ISSN: | 1878-1667 |
| Popis: | This study was undertaken to assess the effects of T. equi infection on serum concentrations of some important cytokines including interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β), IL-1α, IL-4, IL-6, IL-8, IL-10, IL-12α, IL-12β, IL-18, as well as total, protein and lipid binding sialic acids (TSA, PBSA and LBSA). Furthermore, any probable relation among the parasitemia, cytokines and sialic acids (SAs) were calculated using Pearson correlation and simple linear regression. Almost 300 draft horses (Kurdish-breed) with age of 3-4 years old from north-west of Iran were examined and an infected group comprised of 28 mares, naturally infected with T. equi, was identified and divided into 3 subgroups according to their parasitemia rates (low1 %, moderate 1-3 % and high 3-5 %). Twenty healthy horses were considered as a control. Characterization and differentiation of piroplasmosis were conducted using routine hematological procedures and specific PCR assay. The results revealed a significant increase (P0.05) in all of the cytokines and SAs in a parasitic burden-dependent fashion. Additionally, a strong and positive relation was detected among the parasitemia, cytokines and SAs. Conclusively, T. equi infection is associated with induction of severe inflammatory processes in horses and SA plays a pivotal role in pathophysiology of the disease as it is tightly correlated with the parasitemia rate. |
| Databáze: | OpenAIRE |
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