Are anti-brain antibodies in multiple sclerosis directed to myelin basic protein? Studies employing the Shiverer mouse mutant
| Autor: | Björn Ryberg, C. Jacque |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Multiple Sclerosis
Encephalomyelitis Antibodies Mice Mice Neurologic Mutants Myelin Antigen medicine Animals Humans Antigens Myelin Sheath biology Multiple sclerosis Brain Myelin Basic Protein Complement System Proteins General Medicine medicine.disease Complement fixation test Myelin basic protein medicine.anatomical_structure Neurology Peripheral nervous system Immunology biology.protein Electrophoresis Polyacrylamide Gel Neurology (clinical) Antibody |
| Zdroj: | Acta Neurologica Scandinavica. 73:247-252 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1986.tb03270.x |
| Popis: | The dysmyelinating mouse mutant Shiverer has a severe and relatively selective deficiency of myelin basic protein (MBP) in the central and peripheral nervous system. Nevertheless, Shiverer brain and control-mouse brain showed similar antigenic titers when tested by a complement fixation assay against a panel of 14 multiple sclerosis (MS) sera and 6 MS CSF samples known to represent several specificities of antibrain antibodies. By analogy with experimental allergic encephalomyelitis, a sensitization to MBP has been proposed in MS. Our results, however, show that antibodies to other CNS antigens are quantitatively more important in this disease. |
| Databáze: | OpenAIRE |
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