Additional file 3 of Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer

Autor: Laha, Dipranjan, Grant, Robert R.C., Mishra, Prachi, Boufraqech, Myriem, Shen, Min, Zhang, Ya-Qin, Hall, Matthew D., Quezado, Martha, De Melo, Michelly Sampaio, Del Rivero, Jaydira, Zeiger, Martha, Nilubol, Naris
Rok vydání: 2022
DOI: 10.6084/m9.figshare.21200626.v1
Popis: Additionalfile 3: Supplementary Table 1. List of 30 selected drugs for combination drug screening in ACC cell lines. Supplementary Table 2. Correlations between mRNA expression of CDKs and cyclin molecules with MKI67 in human ACC from the TCGA cohort Supplementary Table 3. Correlations between mRNA expression of CDKs and cyclin molecules with MELK in human ACC samples from the TCGA cohort. Supplementary Table 4. OTS167 and RGB-286638 combination shows synergistic activity in ACC cells. The combination index (CI) was calculated using the Chou–Talalay method. The CI is determined by the following range: CI < 1, synergistic; CI = 1, additive; CI > 1, antagonistic. Supplementary Table 5. Correlations between mRNA expression of MELK and β-catenin regulatory molecules in human ACC samples from the TCGA cohort Supplementary Table 6. Correlations between mRNA expression of CDKs and cyclin molecules with STMN1 in human ACC samples from the TCGA cohort Supplementary Table 7. List of Antibodies.
Databáze: OpenAIRE