Structure, function, and defect tolerance with maturation of the radial tie fiber network in the knee meniscus
| Autor: | Miltiadis H. Zgonis, Olivia C. O'Reilly, Sonia Bansal, Dawn M. Elliott, Robert L. Mauck, Niobra M. Keah, John M. Peloquin |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Fibrillar Collagens 0206 medical engineering Fiber network Young's modulus 02 engineering and technology Meniscus (anatomy) Menisci Tibial Article 03 medical and health sciences symbols.namesake 0302 clinical medicine medicine Animals Orthopedics and Sports Medicine Fiber 030203 arthritis & rheumatology Structure function 020601 biomedical engineering Radial direction Knee meniscus Microscopy Fluorescence Multiphoton medicine.anatomical_structure symbols Cattle Resilience (materials science) Biomedical engineering |
| Zdroj: | J Orthop Res |
| ISSN: | 1554-527X 0736-0266 |
| DOI: | 10.1002/jor.24697 |
| Popis: | The knee menisci are comprised of two orthogonal collagenous networks – circumferential and radial – that combine to enable efficient load bearing by the tissue in adults. Here, we assessed how the structural and functional characteristics of these networks developed over the course of skeletal maturation and determined the role of these fiber networks in defect tolerance with tissue injury. Imaging of the radial tie fiber (RTF) collagen structure in medial bovine menisci from fetal, juvenile, and adult specimens showed increasing heterogeneity, anisotropy, thickness, and density with skeletal development. Mechanical analysis showed that the tensile modulus in the radial direction did not change with skeletal development, though the resilience (in the radial direction) increased and the tolerance to defects in the circumferential direction decreased, in adult compared to fetal tissues. This loss of defect tolerance correlated with increased order in the RTF network in adult tissue. These data provide new insights into the role of the radial fiber network in meniscus function, will lead to improved clinical decision-making in the presence of a tear, and may improve engineering efforts to reproduce this critical load-bearing structure in the knee. |
| Databáze: | OpenAIRE |
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