Clostridium difficile and Clostridium sordellii toxins, proinflammatory versus anti-inflammatory response

Autor: Michel R. Popoff
Přispěvatelé: Bactéries anaérobies et Toxines, Institut Pasteur [Paris], Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Toxic shock
MESH: Enterotoxins/immunology
Inflammasomes
[SDV]Life Sciences [q-bio]
Clostridium sordellii
MESH: Bacterial Toxins/toxicity
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Toxicology
medicine.disease_cause
Inflammasome
Enterotoxins
MESH: Bacterial Proteins/immunology
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
MESH: Clostridium sordellii/chemistry
C. sordellii hemorrhagic toxin
biology
Chemistry
Clostridium difficile
C. sordellii lethal toxin
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
MESH: Clostridium difficile/chemistry
Cytokines
MESH: Bacterial Toxins/immunology
medicine.drug
Ras-GTPase
Bacterial Toxins
Clostridium difficile toxin A
Clostridium difficile toxin B
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
MESH: Models
Immunological
Microbiology
Proinflammatory cytokine
03 medical and health sciences
MESH: Inflammasomes/physiology
Bacterial Proteins
MESH: Enterotoxins/toxicity
medicine
Humans
Rho-GTPase
Inflammation
MESH: Humans
Clostridioides difficile
Toxin
Models
Immunological
Toxic shock syndrome
C. difficile toxin A
MESH: Cytokines/immunology
C. difficile toxin B
medicine.disease
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
030104 developmental biology
MESH: Bacterial Proteins/toxicity
MESH: rhoA GTP-Binding Protein/immunology
rhoA GTP-Binding Protein
Zdroj: Toxicon
Toxicon, Elsevier, 2018, 149, pp.54-64. ⟨10.1016/j.toxicon.2017.11.003⟩
Toxicon, 2018, 149, pp.54-64. ⟨10.1016/j.toxicon.2017.11.003⟩
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2017.11.003⟩
Popis: International audience; Clostridium difficile and Clostridium sordellii produce related potent toxins (C. difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and hemorrhagic toxin (TcsH)) which belong to the large clostridial glucosylating toxin (LCGT) family. TcsL is the main C. sordellii toxin as most of toxigenic C. sordellii strains only synthesize this toxin. Intestinal colonization by C. difficile subsequently to unbalanced microbiota is accompanied by release of toxins which induce local tissue destruction and severe inflammatory response. TcdA and TcdB inactivate Rho-GTPases. Notably inactivation of RhoA results in the stimulation of the pyrin/ASC inflammasome, which is one of the main signaling pathways used by these toxins to trigger the inflammatory response. In contrast, TcsL induces an anti-inflammatory effect, mainly by inactivating Ras proteins which results in blockage of the cell cycle and killing of immune cells. The absence or moderate local inflammatory response allows C. sordellii spreading in deep tissues, production of toxin which is released in the general circulation and causes a toxic shock syndrome. The toxin mechanisms of pro-versus anti-inflammatory responses are discussed.
Databáze: OpenAIRE
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