The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition
| Autor: | Kadir Mutlu Hayran, Duru Onan, Ahu Yorulmaz, Fatih Süheyl Ezgü, Seray Cakmak Kulcu, Başak Yalçin, Refika Ferda Artüz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Interferon-Induced Helicase IFIH1 endocrine system diseases Vitiligo Single-nucleotide polymorphism Locus (genetics) 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Article Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine single nucleotide polymorphism Statistical significance Genotype medicine SNP Humans Genetic Predisposition to Disease genes Gene Genetics 0303 health sciences IFIH1 Gene 030306 microbiology business.industry General Medicine Middle Aged medicine.disease Vitiligo single nucleotide polymorphism genes Case-Control Studies business |
| Zdroj: | Turkish Journal of Medical Sciences Volume: 49, Issue: 1 206-211 |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | Background and Aim: Interferon-induced helicase (IFIH1) is a gene locus that has been recently defined as a candidate for susceptibility to generalized vitiligo (GV). The objectives of this study were to assess the association of IFIH1 gene, rs2111485 and rs1990760 single-nucleotide polymorphisms (SNP) with susceptibility to GV and the autoimmune diseases accompanying to GV. Materials and Methods: We prospectively studied GV patients and frequency-matched healthy controls by age and gender. The genotypes of the participants were determined for rs1990760 and rs2111485 SNPs of IFIH1. Dominant, recessive and additive models were evaluated for each SNP adjusted for age and gender. Results: The patients and their controls were demonstrated to be in the Hardy-Weinberg equilibrium for SNP1 (2q24.2, rs1990760, IFIH1, T/C) and SNP2 (2q24.2, rs2111485, IFIH1, G/A) respectively (all p> 0.7). For SNP1 every T allel addition was significantly associated with 1.53 times protectiveness in terms of vitiligo risk (P= 0.033). As for SNP2 every G allel addition was associated with 1.42 times protectiveness, close to statistical significance (P= 0.100). Conclusions: We detected that for SNP1 each T allel and for SNP2 each G allel are protective in terms of vitiligo development. Hereby, we confirmed that IFIH1 gene locus has a role in GV susceptibility. Keywords: Vitiligo, single nucleotide polymorphism, genes |
| Databáze: | OpenAIRE |
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