Response to IGF-1 Generation Test in Short Prepubertal Children Born Very Preterm or at Term
| Autor: | Valentina Chiavaroli, José G. B. Derraik, Paul L. Hofman, Wayne S. Cutfield, Harriet L. Miles |
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| Rok vydání: | 2015 |
| Předmět: |
Leptin
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Short stature Indirect evidence Endocrinology Insulin resistance Internal medicine Humans Insulin Medicine Insulin-Like Growth Factor I Child Growth Disorders Human Growth Hormone business.industry medicine.disease Body Height Recombinant Proteins Very preterm Insulin-Like Growth Factor Binding Protein 3 Premature birth Infant Extremely Premature Pediatrics Perinatology and Child Health Female Insulin Resistance medicine.symptom Carrier Proteins business |
| Zdroj: | Hormone Research in Paediatrics. 84:298-304 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000439233 |
| Popis: | Aims: To investigate whether short children born very preterm (Methods: We studied 26 prepubertal children (aged 7.0 ± 2.0 years) with short stature (height adjusted for parents' heights Results: At baseline, preterm children had lower IGF-binding protein 1 (IGFBP-1; -22%; p = 0.049) and IGFBP-3 (-24%; p = 0.013) concentrations than term children. Preterm children also had insulin concentrations that tended to be 39% higher (p = 0.059) than term peers. After stimulation, IGF-1 and IGFBP-3 concentrations increased similarly in term and preterm groups, while GH-binding protein (GHBP) concentrations decreased in both groups. Preterm children had higher GHBP (+50%; p = 0.049), insulin (+86%; p = 0.005), and leptin (+107%; p = 0.020) but lower IGFBP-1 (-47%; p = 0.006) concentrations than term children following rhGH stimulation. Conclusions: Preterm children who are short for genetic height potential show no evidence of GH resistance that would explain their short stature. However, there was indirect evidence of insulin resistance in the preterm children, as previously described in this group. |
| Databáze: | OpenAIRE |
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