Linfoma de Burkitt en pacientes HIV positivo tratados con quimioterapia intensiva en el Hospital del Salvador entre 2011 y 2014: Protocolo Nacional de Cáncer del Adulto, Chile
| Autor: | Barbara Puga L, Javiera Molina E, Katherinne Bustamante K, Alejandro Andrade M |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Pediatrics business.industry medicine.medical_treatment Incidence (epidemiology) Burkitt lymphoma HIV General Medicine medicine.disease Surgery Lymphoma Serology hemic and lymphatic diseases Medicine Rituximab Antineoplastic protocols Young adult business Febrile neutropenia Immunodeficiency medicine.drug |
| Zdroj: | Revista médica de Chile v.143 n.12 2015 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| DOI: | 10.4067/s0034-98872015001200001 |
| Popis: | Background: Burkitt lymphoma has a low incidence, is highly aggressive, may be endemic, sporadic or associated with immunodeficiency and it has a high frequency of extranodal involvement. Overall and relapse free survival in HIV patients is 72 and 71% respectively. However, the current protocol in Chile considers a positive HIV serology as an exclusion criterion for intensive chemotherapy. Aim: To analyze the response to Burkitt lymphoma treatment among HIV positive patients. Material and Methods: All HIV positive patients with a Burkitt lymphoma treated using PANDA protocol in a public hospital were analyzed. Results: Eight male patients aged between 25 and 43 years, 63% in stage IV, were analyzed. All patients received an intensified chemotherapy regime, three of them without Rituximab. Complete remission was achieved in 87%. One patient was refractory to treatment and one patient relapsed at 5 months and died. Overall and relapse free survival were 58 and 60% respectively. All patients had episodes of high risk febrile neutropenia, but it did not cause deaths. Conclusions: In this group of HIV patients, intensive chemotherapy for Burkitt lymphoma had a high degree of effectiveness with a low relapse rate and high cure rate. |
| Databáze: | OpenAIRE |
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