Plasma endothelin-1 and mean arterial pressure in the prediction of pre-eclampsia
| Autor: | Mohamed Shaarawy, A.-M.A Abdel-Magid |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Mean arterial pressure Adolescent Population Blood Pressure Sensitivity and Specificity Body Mass Index Preeclampsia Pre-Eclampsia Predictive Value of Tests Pregnancy Internal medicine Blood plasma medicine Humans education reproductive and urinary physiology education.field_of_study Eclampsia Endothelin-1 business.industry Obstetrics Obstetrics and Gynecology General Medicine medicine.disease Pregnancy Trimester First Endocrinology Blood pressure ROC Curve Gestation Female Endothelin receptor business |
| Zdroj: | International Journal of Gynecology & Obstetrics. 68:105-111 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/s0020-7292(99)00180-0 |
| Popis: | Objective: To determine whether increased first trimester plasma endothelin-1 and/or increased midtrimester mean arterial blood pressure detected in pregnant women who are free of symptoms can predict the subsequent development of pre-eclampsia. Method: Eighty pregnant women were successfully followed from 10 weeks gestation until delivery. Pre-eclampsia and eclampsia developed in 29 and 2 women, respectively, whereas 49 women remained normotensive. Plasma endothelin-1 was determined in the first trimester (10–12 weeks gestation) by a competitive radioimmunoassay. Result: First trimester plasma endothelin-1 levels in pregnant women who subsequently developed mild, severe pre-eclampsia and eclampsia were significantly higher than those of pregnant women who remained normotensive. The release of endothelin-1 increases with the severity of the disease, age, body mass index and mean arterial blood pressure. The predictive values of plasma endothelin-1 for pre-eclampsia were: sensitivity 96.8%, specificity 51%, positive predictive value 55.5% and negative predictive value 91%, whereas those of MAP were 48.4, 45, 35.7 and 58%, respectively. Conclusion: Determination of first trimester plasma endothelin level may be a valuable marker to identify 55.5% of individuals at high risk of developing pre-eclampsia, if combined with midtrimester MAP, the positive predictive value increases to 68.2%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text