The Course of Neuropathic Symptoms in Relation to Adjuvant Chemotherapy Among Elderly Patients With Stage III Colon Cancer: A Longitudinal Study

Autor: Gerrit D. Slooter, Jan H. Wijsman, Felice N. van Erning, Art Vreugenhil, Maryska L.G. Janssen-Heijnen, Valery E.P.P. Lemmens, Lonneke V. van de Poll-Franse, Tonneke Beijers, Johannes A. Wegdam
Přispěvatelé: Epidemiologie, RS: GROW - R1 - Prevention, Public Health
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Numbness
Organoplatinum Compounds
Colorectal cancer
medicine.medical_treatment
Antineoplastic Agents
HAND-FOOT SYNDROME
CAPECITABINE
Capecitabine
03 medical and health sciences
0302 clinical medicine
Quality of life
SDG 3 - Good Health and Well-being
QUALITY-OF-LIFE
Humans
Medicine
Tingling
Longitudinal Studies
030212 general & internal medicine
Aged
Neoplasm Staging
Aged
80 and over
SURVIVORS
Chemotherapy
business.industry
INDUCED PERIPHERAL NEUROPATHY
Gastroenterology
Peripheral Nervous System Diseases
Cancer
NSABP C-07
medicine.disease
Surgery
Cancer registry
Oxaliplatin
Neuropathy
Peripheral neuropathy
Oncology
Chemotherapy
Adjuvant
CLINICAL-PRACTICE
NEUROTOXICITY
030220 oncology & carcinogenesis
Colonic Neoplasms
Female
business
PROFILES REGISTRY
medicine.drug
Zdroj: Clinical Colorectal Cancer, 16(3), 195-203. CIG Media Group, L.P.
Clinical Colorectal Cancer, 16(3), 195-203. Elsevier
ISSN: 1533-0028
Popis: The course of neuropathic symptoms among elderly patients with stage III colon cancer treated with CAPOX (capecitabine, oxaliplatin), capecitabine, or no chemotherapy was investigated. A total of 117 patients (76%) selected from the Netherlands Cancer Registry completed the first questionnaire. The course of several sensory symptoms was less favorable for patients treated with chemotherapy. Moreover, CAPOX was associated with more symptoms in the toes and feet than was capecitabine.Introduction: Among the elderly, the impairment of functional capacities due to neuropathy can have a significant impact. The aim of the present study was to investigate the course of neuropathic symptoms among elderly patients with stage III colon cancer treated with CAPOX (capecitabine, oxaliplatin), capecitabine monotherapy, or no adjuvant chemotherapy. Materials and Methods: The Netherlands Cancer Registry was used to select patients with stage III colon cancer and aged >= 70 years. Questionnaires were sent after resection (T1) and 6 (T2) and 12 months (T3) later. Neuropathy was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Chemotherapy- Induced Peripheral Neuropathy 20. Logistic generalized estimating equations analyses were used to evaluate the effect of chemotherapy on the course of neuropathic symptoms. Results: Of 155 eligible patients, 117 (76%) completed the T1 questionnaire, and 69 and 59 completed the T2 and T3 questionnaires, respectively. The course of the sensory symptoms tingling fingers or hands, tingling toes or feet, numbness in fingers or hands, and numbness in toes or feet was significantly unfavorable for patients treated with adjuvant chemotherapy (CAPOX or capecitabine) compared with that for patients who had not received adjuvant chemotherapy. The course of numbness in toes or feet also differed significantly between patients treated with CAPOX (T1, 7%; T2, 50%; T3, 42%) and patients treated with capecitabine (T1, 17%; T2, 31%; T3, 8%). Additionally, patients treated with capecitabine reported significantly less tingling toes or feet (T1, 6%; T2, 25%; T3, 7%) compared with patients treated with CAPOX (T1, 0%; T2, 50%; T3, 58%). Conclusion: The course of several sensory symptoms over time was less favorable for elderly patients with colon cancer treated with chemotherapy. Moreover, CAPOX was associated with more symptoms in toes and feet compared with capecitabine. It is important to inform patients of these risks to enable informed decision-making.
Databáze: OpenAIRE
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