Efficacy and Tolerability of Angiotensin II Type 1 Receptor Antagonists in Dialysis Patients Using AN69 Dialysis Membranes
| Autor: | Walter Zidek, Martin Tepel, M. van der Giet |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Tetrazoles Blood Pressure Pharmacology Renal Dialysis Drug tolerance Internal medicine medicine Humans Renal Insufficiency Antihypertensive Agents Aged Angiotensin Receptor Antagonists Angiotensin II receptor type 1 business.industry Biphenyl Compounds Membranes Artificial Valine Drug Tolerance General Medicine Middle Aged Angiotensin II Candesartan Endocrinology Blood pressure Valsartan Tolerability Nephrology Hypertension Benzimidazoles Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Kidney and Blood Pressure Research. 24:71-74 |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Aims and Methods: Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT1) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients with elevated blood pressure. The patients (6 male, 5 female; mean age ± SD 61±11 years) were on regular bicarbonate hemodialysis three times weekly for more than 3 months using acrylonitrile and sodium methallyl sulfonate copolymer (AN69) dialysis membranes. Results: Within 252 days after administration of the AT1 receptor antagonists the systolic blood pressure was significantly reduced from 161±13 to 130±12 mmHg (p0.05). In addition, heart rate (75±7 vs. 80±8/min), body weight, and laboratory variables (hemoglobin, creatinine, blood urea nitrogen, serum potassium, serum sodium, serum calcium, and total protein) showed no significant changes. During 1,188 hemodialysis sessions using AN69 membranes, no hypersensitivity reactions occurred after administration of AT1 receptor antagonists. Conclusion: The results indicate that once–daily administration of AT1 receptor antagonists efficiently reduces the systolic blood pressure in hemodialysis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|