Characterization and differentiation of cyclopropylfentanyl from E-crotonylfentanyl, Z-crotonylfentanyl, and 3-butenylfentanyl
| Autor: | John F. Casale, Patrick A. Hays, Jennifer R. Mallette |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Magnetic Resonance Spectroscopy
Illicit Drugs Chemistry 010401 analytical chemistry Forensic chemistry Nuclear magnetic resonance spectroscopy Mass spectrometry 01 natural sciences Gas Chromatography-Mass Spectrometry 0104 chemical sciences Pathology and Forensic Medicine Characterization (materials science) Analgesics Opioid Fentanyl 03 medical and health sciences 0302 clinical medicine Isomerism Computational chemistry Spectroscopy Fourier Transform Infrared Mass spectrum Illicit drug 030216 legal & forensic medicine Fourier transform infrared spectroscopy |
| Zdroj: | Science & Justice. 59:67-74 |
| ISSN: | 1355-0306 |
| DOI: | 10.1016/j.scijus.2018.07.005 |
| Popis: | Recently, a sample containing cyclopropylfentanyl was analyzed at this laboratory. Cyclopropylfentanyl began to appear in the United States' illicit drug markets in 2017. Unfortunately, cyclopropylfentanyl presents an analytical challenge due to its mass spectrum being almost identical to that of crotonylfentanyl. There are two possible isomers of crotonylfentanyl, Z- and E- crotonylfentanyl. In order to provide sufficient analytical data to distinguish the two isomers of crotonylfentanyl and cyclopropylfentanyl, crotonylfentanyl was synthesized and fully characterized. Each isomer was analyzed via nuclear magnetic resonance spectroscopy, gas chromatography-mass spectrometry, and Fourier transform infrared spectroscopy. During the synthesis of crotonylfentanyl, an unknown compound was formed. The identification of this compound and the analytical characterization of the two isomers of crotonylfentanyl are presented. Through the comparison of these compounds, it was confirmed that cyclopropylfentanyl can be differentiated from crotonylfentanyl. |
| Databáze: | OpenAIRE |
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