The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression
| Autor: | Annalise E Zemlin, Hayley Ipp, Careen L Hudson |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adenosine Deaminase Clinical Biochemistry HIV Infections Inflammation Disease CD8-Positive T-Lymphocytes Arginine Asymptomatic chemistry.chemical_compound Adenosine deaminase HIV Seropositivity medicine Humans Endothelial dysfunction biology Interleukin-6 business.industry General Medicine Viral Load medicine.disease CD4 Lymphocyte Count Cross-Sectional Studies chemistry Cardiovascular Diseases Case-Control Studies Immunoglobulin G Immunology biology.protein Female medicine.symptom business Asymmetric dimethylarginine Viral load Biomarkers CD8 |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 51:568-575 |
| ISSN: | 1758-1001 0004-5632 |
| Popis: | Background As lifespan in HIV infection increases, cardiovascular disease has emerged as a cause of morbidity and mortality. Asymmetric dimethylarginine is an established marker of endothelial dysfunction and predicts cardiovascular events. The role of asymmetric dimethylarginine in HIV-related cardiovascular disease has not been established. Our aim was to determine whether asymmetric dimethylarginine concentrations were elevated in treatment naïve, HIV-infected subjects and to correlate these with markers of immune activation and disease progression. Methods Serum samples were collected from HIV-positive and -negative subjects attending a primary health care clinic over a 12-month period. Asymmetric dimethylarginine concentrations were measured and correlated with CD4 count, viral load, hsCRP, IL-6, IgG, adenosine deaminase and CD8/38 T lymphocytes. Results Sixty HIV-positive participants (mean age 32.0 years) and 20 HIV-negative controls (mean age 32.4 years) were studied. All were of black ethnicity. The mean asymmetric dimethylarginine concentration in the infected group measured 0.67 µmol/L (95% CI 0.62–0.72 µmol/L) which was significantly higher than in the control group of 0.48 µmol/L (95% CI 0.40–0.56 µmol/L). Asymmetric dimethylarginine correlated inversely with CD4 counts and positively with IgG, adenosine deaminase and CD8/38 T lymphocytes. No significant correlation was found with hsCRP, IL-6, or viral load. Conclusion We demonstrated that asymmetric dimethylarginine is elevated in HIV infection, in patients with relatively well-preserved CD4 counts not yet on anti-retroviral treatment. We showed significant correlations of asymmetric dimethylarginine with CD8/38 T lymphocytes, IgG and adenosine deaminase, suggesting that T-cell activation and the adaptive immune response underlie asymmetric dimethylarginine elevation in this population. |
| Databáze: | OpenAIRE |
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