The dark side of high-frequency oscillations in the developing brain
| Autor: | Michel Le Van Quyen, Yehezkel Ben-Ari, Ilgam Khalilov |
|---|---|
| Přispěvatelé: | Neurosciences cognitives et imagerie cérébrale (NCIC), Centre National de la Recherche Scientifique (CNRS), Epilepsie et ischémie cérébrale, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Tyzio, Roman |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Brain development
Central nervous system MESH: Neurons Glutamic Acid High-Frequency Ventilation Neurological disorder MESH: gamma-Aminobutyric Acid Synaptic Transmission Synapse Glutamatergic Epilepsy MESH: Brain Oscillometry medicine MESH: Synaptic Transmission Animals Humans MESH: Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Oscillometry gamma-Aminobutyric Acid Neurons MESH: High-Frequency Ventilation MESH: Humans General Neuroscience [SCCO.NEUR]Cognitive science/Neuroscience Brain MESH: Glutamic Acid medicine.disease Developmental disorder medicine.anatomical_structure MESH: Nerve Net Excitatory postsynaptic potential [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Nerve Net Psychology Neuroscience |
| Zdroj: | Trends in Neurosciences Trends in Neurosciences, 2006, 29 (7), pp.419-27. ⟨10.1016/j.tins.2006.06.001⟩ Trends in Neurosciences, 2006, 29 (7), pp.419-427. ⟨10.1016/j.tins.2006.06.001⟩ |
| ISSN: | 0166-2236 1878-108X |
| DOI: | 10.1016/j.tins.2006.06.001⟩ |
| Popis: | International audience; Adult brain networks generate a wide range of oscillations. Some of these are behaviourally relevant, whereas others occur during seizures and other pathological conditions. This raises the question of how physiological oscillations differ from pathogenic ones. In this review, this issue is discussed from a developmental standpoint. Indeed, both epileptic and physiological high-frequency oscillations (HFOs) appear progressively during maturation, and it is therefore possible to determine how this program corresponds to maturation of the neuronal populations that generate these oscillations. We review here important differences in the development of neuronal populations that might contribute to their different oscillatory properties. In particular, at an early stage, the density of glutamatergic synapses is too low for physiological HFOs but an additional drive can be provided by excitatory GABA, triggering epileptic HFOs and the cascades involved in long-lasting epileptogenic transformations. This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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