Decreased adrenergic tone in acromegaly: evidence from direct recording of muscle sympathetic nerve activity
| Autor: | Chiara Carzaniga, C. Facchini, Roberto Attanasio, Massimo Scacchi, Gino Seravalle, Guido Grassi, Giovanna Sciortino, F. Cavagnini, Sarah Damanti, Renato Cozzi, G. Mancia, Giovanni Vitale, Laura Lonati, M. Montini, Gianmaria Brambilla, Letizia Maria Fatti |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Sympathetic Nervous System Endocrinology Diabetes and Metabolism Adrenergic Endocrinology Insulin resistance Anterior pituitary Internal medicine Acromegaly medicine Humans Aged business.industry Hyperprolactinaemia Case-control study Middle Aged Lipid Metabolism medicine.disease medicine.anatomical_structure Case-Control Studies Female Insulin Resistance business Body mass index |
| Zdroj: | Clinical Endocrinology. 77:262-267 |
| ISSN: | 0300-0664 |
| Popis: | SummaryObjective Sympathovagal imbalance has been shown in acromegaly by indirect measurements of adrenergic tone. Data regarding direct measurement of sympathetic activity are lacking as yet. Aim of this study was to assess the adrenergic tone through direct recording of muscle sympathetic nerve activity (MSNA) in acromegalic patients. Design Fifteen patients (age 26–66 years, eight women) with newly diagnosed active acromegaly without hyperprolactinaemia, pituitary hormone deficiencies, obstructive sleep apnoea and cardiac hypertrophy, and 15 healthy subjects matched for age, sex and body mass index were recruited. After evaluating anthropometric and echocardiographic parameters, anterior pituitary function, glucose and lipid metabolism, and measuring plasma leptin, direct recording of sympathetic outflow via the microneurographic technique was performed. Results For similar anthropometric and metabolic parameters in patients and controls, HOMA index was significantly increased in the former (4·2 ± 2·39 vs 1·6 ± 0·19, P |
| Databáze: | OpenAIRE |
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