The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital

Autor: Prosper Okonkwo, Jay Osi Samuels, Akin Osibogun, Seema T. Meloni, Titilope A Adeyemo, Raph L. Hamers, Kim C. E. Sigaloff, Ann Abiola Ogbenna, Phyllis J. Kanki, Tobias F. Rinke de Wit, Seth C Inzaule, Alani S Akanmu
Přispěvatelé: Global Health, AII - Infectious diseases, APH - Personalized Medicine, APH - Quality of Care, Intensive care medicine, Internal medicine
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
RNA viruses
Male
Epidemiology
Treatment outcome
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Pathology and Laboratory Medicine
Geographical Locations
Cohort Studies
0302 clinical medicine
Immunodeficiency Viruses
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Longitudinal Studies
Immune Response
Multidisciplinary
Medical record
Viral Load
Middle Aged
Vaccination and Immunization
Treatment Outcome
Medical Microbiology
HIV epidemiology
Research Design
Viral Pathogens
Viruses
Female
Pathogens
Viral load
Cohort study
Research Article
Adult
medicine.medical_specialty
Universities
Anti-HIV Agents
Science
Immunology
Antiretroviral Therapy
Nigeria
Research and Analysis Methods
Microbiology
Virus
03 medical and health sciences
Antiviral Therapy
Internal medicine
Virology
Retroviruses
Humans
Genetic variability
Hospitals
Teaching
Microbial Pathogens
business.industry
Lentivirus
Organisms
Biology and Life Sciences
HIV
Antiretroviral therapy
CD4 Lymphocyte Count
030104 developmental biology
People and Places
Africa
HIV-1
Preventive Medicine
business
Viral Transmission and Infection
Zdroj: PLoS ONE, Vol 15, Iss 8, p e0238027 (2020)
PLoS ONE, 15(8 August):e0238027. Public Library of Science
Ogbenna, A A, Meloni, S, Inzaule, S, Hamers, R L, Sigaloff, K, Osibogun, A, Adeyemo, T A, Okonkwo, P, Samuels, J O, Kanki, P J, de Wit, T F R & Akanmu, A S 2020, ' The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital : A longitudinal evaluation ', PLoS ONE, vol. 15, no. 8, e0238027 . https://doi.org/10.1371/journal.pone.0238027, https://doi.org/10.1371/journal.pone.0238027
PLoS ONE
PLoS ONE, 15(8):e0238027. Public Library of Science
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0238027
Popis: Introduction HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes. Materials and methods We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were extracted from medical records. Whole protease gene and codon 1–300 of the reverse transcriptase gene were sequenced and analysed. Results Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All subtypes showed steady rise in CD4 count and there was no difference in proportion who achieved CD4+ cell count rise of ≥100 cells/μL from baseline within 12 months’ post-initiation of ART, or ≥350 cells/μL at 60 months’ post-initiation. Median time to attaining a rise of ≥350 cells/μL was 24 months (6–48 months). The proportion that achieved undetectable VL at month 6 and 12 post-initiation of ART were comparable across subtypes. At end of 5th year, there was no statistical difference in proportion with virologic failure. Conclusion No association between HIV subtypes and immunologic or virologic response to therapy was observed, suggesting that current first-line ART may have similar efficacy across subtype predominating in South-West Nigeria.
Databáze: OpenAIRE
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