IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy
| Autor: | Xavier Jaumont, Marc Humbert, Nikolaos G. Papadopoulos, Ioannis Kottakis, Oscar Palomares, Jean Bousquet, Simon Francis Thomsen, Pascal Pfister, Claus Bachert |
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| Přispěvatelé: | Hôpital Bicêtre, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Ghent University Hospital, National and Kapodistrian University of Athens (NKUA) |
| Rok vydání: | 2019 |
| Předmět: |
Hypersensitivity
Immediate Allergy CHRONIC RHINOSINUSITIS Omalizumab Immunoglobulin E FOOD ALLERGY Allergic rhinitis DOUBLE-BLIND 0302 clinical medicine immune system diseases Anti-Allergic Agents Medicine and Health Sciences ATOPIC-DERMATITIS Immunology and Allergy 030212 general & internal medicine [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology Conjunctivitis Allergic biology Atopic dermatitis 3. Good health Multimorbidities RAPID ORAL DESENSITIZATION [SDV.IMM]Life Sciences [q-bio]/Immunology MAST-CELLS Allergic bronchopulmonary aspergillosis Food Hypersensitivity medicine.drug CASE SERIES Dermatitis Atopic 03 medical and health sciences Nasal Polyps Rhinoconjunctivitis Food allergy medicine Humans Vernal keratoconjunctivitis Sinusitis Asthma BRONCHOPULMONARY ASPERGILLOSIS business.industry Aspergillosis Allergic Bronchopulmonary Multimorbidity medicine.disease Rhinitis Allergic Chronic rhinosinusitis with nasal polyps respiratory tract diseases Treatment ANTI-IGE 030228 respiratory system VERNAL KERATOCONJUNCTIVITIS Food allergies Chronic Disease Immunology biology.protein business |
| Zdroj: | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE Journal of Allergy and Clinical Immunology: In Practice Journal of Allergy and Clinical Immunology: In Practice, Elsevier, 2019, 7 (5), pp.1418-1429. ⟨10.1016/j.jaip.2019.02.030⟩ Humbert, M, Bousquet, J, Bachert, C, Palomares, O, Pfister, P, Kottakis, I, Jaumont, X, Thomsen, S F & Papadopoulos, N G 2019, ' IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy ', The Journal of Allergy and Clinical Immunology: In Practice, vol. 7, no. 5, pp. 1418-1429 . https://doi.org/10.1016/j.jaip.2019.02.030 |
| ISSN: | 2213-2198 |
| Popis: | Allergic asthma often coexists with different pathological conditions, called multimorbidities, that are mostly of allergic nature and share a common underlying inflammatory pathophysiological mechanism. Multimorbidities of allergic asthma may influence asthma control, its severity, and patients' response to treatment, and contribute to the overall socioeconomic burden of the disease. Immunoglobulin E (IgE) is known to play a central role in the pathogenesis of various allergic diseases, including asthma. Thus, IgE-mediated immunologic pathways present an attractive target for intervention in asthma and multimorbidities. In this review, we discuss the most frequently reported IgE-mediated multimorbidities in allergic asthma, including allergic rhinitis, rhinoconjunctivitis, atopic dermatitis, vernal keratoconjunctivitis, chronic rhinosinusitis with nasal polyps, food allergies, and allergic bronchopulmonary aspergillosis. Omalizumab is a recombinant humanized monoclonal antibody against IgE and has been in use to treat allergic asthma for more than a decade. We comprehensively review the clinical evidence for omalizumab in the treatment of the aforementioned multimorbidities in allergic asthma. (C) 2018 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology |
| Databáze: | OpenAIRE |
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