S‐allyl cysteine, an active ingredient of garlic, attenuates acute liver dysfunction induced by lipopolysaccharide/ d ‐galactosamine in mouse: Underlying mechanisms

Autor: Alireza Shahmohammadi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Seyed-Mohamad-Sadegh Mirahmadi, Samira Ramzi, Ali-Mohammad Rousta
Rok vydání: 2020
Předmět:
Zdroj: Journal of Biochemical and Molecular Toxicology. 34
ISSN: 1099-0461
1095-6670
DOI: 10.1002/jbt.22518
Popis: In the present study, beneficial effect of S-allyl cysteine (SAC) was evaluated in the lipopolysaccharide/d-galactosamine (LPS/d-Gal) model of acute liver injury (ALI). To mimic ALI, LPS and d-Gal (50 I¼g/kg and 400 mg/kg, respectively) were intraperitoneally administered and animals received SAC per os (25 or 100 mg/kg/d) for 3 days till 1 hour before LPS/d-Gal injection. Pretreatment of LPS/d-Gal group with SAC-lowered activities of alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase and partially reversed inappropriate alterations of hepatic oxidative stress- and inflammation-related biomarkers including liver reactive oxygen species, malondialdehyde, and hepatic activity of the defensive enzyme superoxide dismutase, ferric reducing antioxidant power (FRAP), toll-like receptor-4 (TLR4), cyclooxygenase 2, NLR family pyrin domain containing 3 (NLRP3), caspase 1, nuclear factor IoB (NF-IoB), interleukin 1I² (IL-1I²), IL-6, tumor necrosis factor-I±, and myeloperoxidase activity. Additionally, SAC was capable to ameliorate apoptotic biomarkers including caspase 3 and DNA fragmentation. In summary, SAC can protect liver against LPS/d-Gal by attenuation of neutrophil infiltration, oxidative stress, inflammation, apoptosis, and pyroptosis which is partly linked to its suppression of TLR4/NF-IoB/NLRP3 signaling. © 2020 Wiley Periodicals LLC
Databáze: OpenAIRE
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