Aminoglycoside-induced reversible tubular dysfunction

Autor: Evagelos N. Liberopoulos, George Alexandridis, Moses Elisaf
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Male
medicine.medical_specialty
Magnesium/blood/metabolism
Metabolic alkalosis
Renal function
Hypokalemia
Gentamicins/administration & dosage/*adverse effects
Drug Administration Schedule
Hypomagnesemia
Nephrotoxicity
Potassium Chloride
Kidney Tubules
Proximal

Internal medicine
medicine
Humans
Magnesium
Hypouricemia
Alkalosis/chemically induced
Aged
Hypokalemia/chemically induced/metabolism
Pharmacology
urogenital system
business.industry
Aminoglycoside
Potassium Chloride/therapeutic use
Fanconi syndrome
Alkalosis
General Medicine
Magnesium Deficiency/chemically induced/metabolism
Tobramycin/administration & dosage/*adverse effects
medicine.disease
Kidney Tubules
Proximal/*physiopathology

Anti-Bacterial Agents
Endocrinology
Tobramycin
Kidney Diseases
Anti-Bacterial Agents/administration & dosage/*adverse effects
Female
medicine.symptom
Gentamicins
business
Magnesium Deficiency
Kidney Diseases/*chemically induced/physiopathology
Popis: Nonoliguric renal insufficiency is a well-known nephrotoxic consequence of aminoglycosides, although reversible tubular damage in the absence of any change in the renal function has been occasionally found. Reported herein are 2 representative cases of a reversible tubular damage due to prolonged aminoglycoside administration: a patient with a Fanconi-like syndrome of proximal tubular dysfunction and a patient with a syndrome of hypokalemic metabolic alkalosis associated with hypomagnesemia.
Databáze: OpenAIRE